Construction of quaternary stereocenters by efficient and practical conjugate additions to α,β-unsaturated ketones with a chiral organic catalyst

被引：180

作者：

Wu, FH ^{[1
]}

Li, HM ^{[1
]}

Hong, R ^{[1
]}

Deng, L ^{[1
]}

机构：

[1] Brandeis Univ, Dept Chem, Waltham, MA 02454 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 06期

关键词：

alkaloids; conjugate addition; diastereoselectivity; enantioselectivity; enones;

D O I：

10.1002/anie.200502658

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Added value: The conjugate addition of cyclic or acyclic α-substituted β-ketoesters to α,β-unsaturated ketones using a chiral organic catalyst (1) can be achieved with good enantioselectivity, diastereoselectivity, and yield. This asymmetric C-C bond formation strategy provides a range of chiral building blocks 2 that contain an all-carbon quaternary stereocenter. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：947 / 950

页数：4

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