Synthesis, characterization and relaxivity of amphiphilic chelates of DTPA derivatives with Gd-III, Yb-III and Mn-II

被引：20

作者：

Zhao, X

Zhuo, RX

Lu, ZG

Liu, WY

机构：

[1] WUHAN UNIV,DEPT CHEM,WUHAN 430072,PEOPLES R CHINA

[2] ACAD SINICA,WUHAN INST PHYS,WUHAN 430072,PEOPLES R CHINA

来源：

POLYHEDRON | 1997年 / 16卷 / 16期

关键词：

amphiphilic ligand; DTPA derivative; paramagnetic metal complex; MRI contrast agent; relaxivity; liposome;

D O I：

10.1016/S0277-5387(97)00029-6

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Some novel amphiphilic ligands were synthesized by the reaction of diethylenetriaminepentaacetic acid (DTPA) dianhydride and octadecylester of tyrosine or phenylalanine. Their paramagnetic Gd-III, Yb-III and Mn-II metal complexes were also synthesized and characterized. The amphipathic metal complexes were inserted into the membrane of liposomal vesicles and the liposomes bearing metal complexes were obtained. The paramagnetic metal labeled liposomes show high spin-lattice relaxivity (R-1) on the surrounding water protons. (C) 1997 Elsevier Science Ltd.

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收藏

页码：2755 / 2759

页数：5

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