11 beta-aryl steroids in the androstene series. The role of the 11 beta-region in steroid progesterone receptor interaction

被引：20

作者：

Cleve, A

Fritzemeier, KH

Heinrich, N

Klar, U

MullerFahrnow, A

Neef, G

Ottow, E

Schwede, W

机构：

[1] Research Laboratories of Schering AG

来源：

TETRAHEDRON | 1996年 / 52卷 / 05期

关键词：

D O I：

10.1016/0040-4020(95)00983-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The syntheses of 11 beta-arylandrost-4-en-3-one 24 and the corresponding 9 beta,19-cyclo derivative 8 are described Steric interaction between C-19 and the aryl residue effects conformational changes of the steroid ring system that result in reduced affinity for the progesterone receptor. The conformation of 11 beta-arylandrostenes is discussed in comparison with known antiprogestational steroids.

引用

页码：1529 / 1542

页数：14

共 14 条

[1]

CLEVE A, UNPUB

[2]

CLEVE A, 1990, Patent No. 404283

[3] THE DEVELOPMENT AND USE OF QUANTUM-MECHANICAL MOLECULAR-MODELS .76. AM1 - A NEW GENERAL-PURPOSE QUANTUM-MECHANICAL MOLECULAR-MODEL [J].