Influence of the N-methyl-D-aspartate antagonist memantine on human motor cortex excitabirity

被引：142

作者：

Schwenkreis, P

Witscher, K

Janssen, F

Addo, A

Dertwinkel, R

Zenz, M

Malin, JP

Tegenthoff, M

机构：

[1] Ruhr Univ Bochum, BG Kliniken Bergmannsheil, Dept Neurol, D-44789 Bochum, Germany

[2] Ruhr Univ Bochum, BG Kliniken Bergmannsheil, Dept Anesthesiol, D-44789 Bochum, Germany

来源：

NEUROSCIENCE LETTERS | 1999年 / 270卷 / 03期

关键词：

transcranial magnetic stimulation; intracortical facilitation; intracortical inhibition; motor cortex; memantine; N-methy-D-aspartate receptor;

D O I：

10.1016/S0304-3940(99)00492-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The aim of our study was to investigate the effect of the N-methyl-D-aspartate (NMDA) antagonist memantine on motor excitability in humans. Seven healthy volunteers received memantine or placebo, respectively, over a period of 8 days. At day 8, transcranial magnetic stimulation (TMS) was performed using a paired pulses paradigm in order to assess intracortical inhibition and facilitation. Additionally, motor threshold and silent period duration after TMS were measured as well as M waves, F waves and peripheral silent period after electrical peripheral nerve stimulation. Intracortical inhibition was enhanced, and intracortical facilitation reduced after memantine ingestion in comparison to placebo, whereas no significant difference could be observed regarding the other neurophysiological parameters. We conclude that the NM DA receptor is involved in the regulation of excitability of intracortical interneuronal circuits. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：137 / 140

页数：4

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