Human Embryonic Stem Cell Differentiation Toward Regional Specific Neural Precursors

被引：104

作者：

Erceg, Slaven ^{[1
]}

Ronaghi, Mohammad ^{[1
]}

Stojkovic, Miodrag ^{[1
]}

机构：

[1] Ctr Invest Principe Felipe, Cellular Reprogramming Lab, Valencia, Spain

来源：

STEM CELLS | 2009年 / 27卷 / 01期

关键词：

Human embryonic stem cells; Neural differentiation; Cell culture; Cellular therapy; SPINAL-CORD-INJURY; MIDBRAIN DOPAMINERGIC-NEURONS; IN-VITRO DIFFERENTIATION; CENTRAL-NERVOUS-SYSTEM; DIRECTED DIFFERENTIATION; MOTOR-NEURON; OLIGODENDROCYTE DEVELOPMENT; PROGENITOR CELLS; SONIC HEDGEHOG; HUMAN BLASTOCYSTS;

D O I：

10.1634/stemcells.2008-0543

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Human embryonic stem cells (hESCs) are self-renewing pluripotent cells that have the capacity to differentiate into a wide variety of cell types. This potentiality represents a promising source to overcome many human diseases by providing an unlimited supply of all cell types, including cells with neural characteristics. Therefore, this review summarizes early neural development and the potential of hESCs to differentiate under in vitro conditions, examining at the same time the potential use of differentiated hESCs for therapeutic applications for neural tissue and cell regeneration. STEM CELLS 2009; 27: 78-87

引用

页码：78 / 87

页数：10

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