RNA editing: Getting U into RNA

被引：47

作者：

Kable, ML

Heidmann, S

Stuart, KD

机构：

[1] UNIV WASHINGTON,DEPT PATHOBIOL,SEATTLE,WA 98195

[2] UNIV BAYREUTH,DEPT GENET,D-95440 BAYREUTH,GERMANY

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1997年 / 22卷 / 05期

关键词：

D O I：

10.1016/S0968-0004(97)01041-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

RNA editing in kinetoplastid protozoa remodels the sequences of mitochondrial pre-mRNAs by the precise insertion and deletion of uridylate residues. These sequence changes are directed by small trans-acting RNAs, termed guide RNAs. The basic mechanistic pathway by which edited RNA is generated has recently been elucidated using in vitro systems capable of a full round of guide-RNA-directed editing.

引用

页码：162 / 166

页数：5

共 27 条

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