The length heuristic for simultaneous hypothesis tests

被引:34
作者
Efron, B
机构
[1] Department of Statistics, Stanford University, Stanford
关键词
Hotelling; O'Brein-Fleming procedure; repeated testing; two-point bound; volume of tubes;
D O I
10.1093/biomet/84.1.143
中图分类号
Q [生物科学];
学科分类号
07 [理学]; 0710 [生物学]; 09 [农学];
摘要
We observe a sequence of test statistics J = (T-1, T-2,..., T-J), each of which is approximately N(0, 1) under the null hypothesis H-0, but which are correlated with each other. Not being certain which T-j is best, we use the test statistic T-max = max{T-1, T-2,..., T-J}. For a given observed value of T-max, say c, what is the significance probability pr(T-max > c)? Define the length of J to be Sigma(j = 2)(J) arccos(rho(j-1,j)), where rho(j-1,j) is the null hypothesis correlation between Tj-1 and T-j. Hotelling's theorem on the volume of tubes leads to a length-based bound on pr(T-max > c) that usually beats the Bonferroni bound. It is easy to improve Hotelling's bound. Several examples show that in favourable circumstances the improved bounds can be good approximations to the actual value of pr(T-max > c).
引用
收藏
页码:143 / 157
页数:15
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