Saccharomyces kluyveri as a model organism to study pyrimidine degradation

被引：12

作者：

Beck, Halfdan ^{[1
]}

Dobritzsch, Doreen ^{[2
]}

Piskur, Jure ^{[1
]}

机构：

[1] Lund Univ, Dept Cell & Organism Biol, SE-22362 Lund, Sweden

[2] Karolinska Inst, Dept Med Biochem & Biophys, Stockholm, Sweden

来源：

FEMS YEAST RESEARCH | 2008年 / 8卷 / 08期

基金：

瑞典研究理事会;

关键词：

nonconventional yeast; structure-function relationship; nucleic acid precursors; pyrimidine; cancer;

D O I：

10.1111/j.1567-1364.2008.00442.x

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The yeast Saccharomyces kluyveri (Lachancea kluyveri), a far relative of Saccharomyces cerevisiae, is not a widely studied organism in the laboratory. However, significant contributions to the understanding of nucleic acid precursors degradation in eukaryotes have been made using this model organism. Here we review eukaryotic pyrimidine degradation with emphasis on the contributions made with S. kluyveri and how this increases our understanding of human disease. Additionally, we discuss the possibilities and limitations of this nonconventional yeast as a laboratory organism.

引用

页码：1209 / 1213

页数：5

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