A short synthesis of oxazolidinone derivatives linezolid and eperezolid : A new class of antibacterials

被引:103
作者
Lohray, BB [1 ]
Baskaran, S [1 ]
Rao, BS [1 ]
Reddy, BY [1 ]
Rao, IN [1 ]
机构
[1] Dr Reddys Res Fdn, Hyderabad 500050, Andhra Pradesh, India
关键词
1,2,5,6-diahydrosugar; Linezolid; Eperezolid; antibacterials;
D O I
10.1016/S0040-4039(99)00893-X
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Oxazolidinone derivatives such as Linezolid and Eperazolid, which are a new class of antibacterials, have been synthesized from 1,2,5,6-dianhydro-3,4-isopropylidine-D-mannitol in good yield. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:4855 / 4856
页数:2
相关论文
共 9 条
[1]   SYNTHESIS OF(R)-EPICHLOROHYDRIN AND (S)-EPICHLOROHYDRIN [J].
BALDWIN, JJ ;
RAAB, AW ;
MENSLER, K ;
ARISON, BH ;
MCCLURE, DE .
JOURNAL OF ORGANIC CHEMISTRY, 1978, 43 (25) :4876-4878
[2]   Synthesis and antibacterial activity of U-100592 and U-100766, two oxazolidinone antibacterial agents for the potential treatment of multidrug-resistant Gram-positive bacterial infections [J].
Brickner, SJ ;
Hutchinson, DK ;
Barbachyn, MR ;
Manninen, PR ;
Ulanowicz, DA ;
Garmon, SA ;
Grega, KC ;
Hendges, SK ;
Toops, DS ;
Ford, CW ;
Zurenko, GE .
JOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (03) :673-679
[3]   New directions in antibacterial research [J].
Chu, DTW ;
Plattner, JJ ;
Katz, L .
JOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (20) :3853-3874
[4]   ANTIBACTERIALS - SYNTHESIS AND STRUCTURE ACTIVITY STUDIES OF 3-ARYL-2-OXOOXAZOLIDINES .1. THE B-GROUP [J].
GREGORY, WA ;
BRITTELLI, DR ;
WANG, CLJ ;
WUONOLA, MA ;
MCRIPLEY, RJ ;
EUSTICE, DC ;
EBERLY, VS ;
BARTHOLOMEW, PT ;
SLEE, AM ;
FORBES, M .
JOURNAL OF MEDICINAL CHEMISTRY, 1989, 32 (08) :1673-1681
[5]   ANTIBACTERIALS - SYNTHESIS AND STRUCTURE ACTIVITY STUDIES OF 3-ARYL-2-OXOOXAZOLIDINES .2. THE A GROUP [J].
GREGORY, WA ;
BRITTELLI, DR ;
WANG, CLJ ;
KEZAR, HS ;
CARLSON, RK ;
PARK, CH ;
CORLESS, PF ;
MILLER, SJ ;
RAJAGOPALAN, P ;
WUONOLA, MA ;
MCRIPLEY, RJ ;
EBERLY, VS ;
SLEE, AM ;
FORBES, M .
JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (09) :2569-2578
[6]   A practical approach to the synthesis of dianhydro sugars [J].
Lohray, BB ;
Chatterjee, M ;
Jayamma, Y .
SYNTHETIC COMMUNICATIONS, 1997, 27 (10) :1711-1724
[7]   ANTIBACTERIALS - SYNTHESIS AND STRUCTURE ACTIVITY STUDIES OF 3-ARYL-2-OXOOXAZOLIDINES .4. MULTIPLY-SUBSTITUTED ARYL DERIVATIVES [J].
PARK, CH ;
BRITTELLI, DR ;
WANG, CLJ ;
MARSH, FD ;
GREGORY, WA ;
WUONOLA, MA ;
MCRIPLEY, RJ ;
EBERLY, VS ;
SLEE, AM ;
FORBES, M .
JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (06) :1156-1165
[8]   A CONVENIENT AND HIGHLY CHEMOSELECTIVE METHOD FOR THE REDUCTIVE ACETYLATION OF AZIDES [J].
ROSEN, T ;
LICO, IM ;
CHU, DTW .
JOURNAL OF ORGANIC CHEMISTRY, 1988, 53 (07) :1580-1582
[9]   MULTIDRUG-RESISTANT ENTEROCOCCUS-FAECIUM - AN UNTREATABLE NOSOCOMIAL PATHOGEN [J].
SPERA, RV ;
FARBER, BF .
DRUGS, 1994, 48 (05) :678-688