Topical Antibiotics in Dermatology: Emerging Patterns of Resistance

被引：41

作者：

Elston, Dirk M. ^{[1
]}

机构：

[1] Geisinger Med Ctr, Dept Dermatol, Danville, PA 17821 USA

来源：

DERMATOLOGIC CLINICS | 2009年 / 27卷 / 01期

关键词：

Bacterial; Resistance; Skin; Acne; Infection; STAPHYLOCOCCUS-AUREUS COLONIZATION; PROPIONIBACTERIUM-ACNES RESISTANCE; RANDOMIZED CONTROLLED-TRIAL; FUSIDIC ACID 2-PERCENT; INTENSIVE-CARE-UNIT; IN-VITRO ACTIVITY; RAT BURN WOUNDS; METHICILLIN-RESISTANT; DOUBLE-BLIND; ANTIMICROBIAL ACTIVITY;

D O I：

10.1016/j.det.2008.07.004

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Resistance to topical antibiotics is increasingly relevant in dermatology. This article discusses emerging patterns of resistance and the implications for clinical practice. Emergence of resistance is complicating decolonization of the skin and nares in patients infected with methicillin-resistant Staphylococcus aureus. In the setting of acne treatment, adding topical benzoyl peroxide has been shown to reduce the emergence of strains resistant to topical antibiotics. Other agents, such as zinc salts, are promising in this regard. This article discusses alternatives to antibiotics and mechanisms to stem the emergence of resistance.

引用

页码：25 / +

页数：8

共 63 条

[1] Comparison of silver sulfadiazine 1%, mupirocin 2%, and fusidic acid 2% for topical antibacterial effect in methicillin-resistant staphylococci-infected, full-skin thickness rat burn wounds [J].

Acikel, C ;

Oncul, O ;

Ulkur, E ;

Bayram, I ;

Celikoz, B ;

Cavuslu, S .

JOURNAL OF BURN CARE & REHABILITATION, 2003, 24 (01) :37-41

[2] Susceptibility of skin and soft-tissue isolates of staphylococcus aureus and streptococcus pyogenes to topical antibiotics:: Indications of clonal spread of fusidic acid-resistant staphylococcus aureus [J].

Afset, JE ;

Mæland, JA .

SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES, 2003, 35 (02) :84-89

[3] An assessment of triclosan susceptibility in methicillin-resistant and methicillin-sensitive Staphylococcus aureus [J].

Bamber, AI ;

Neal, TJ .

JOURNAL OF HOSPITAL INFECTION, 1999, 41 (02) :107-109

[4] Evaluation of chlorhexidine and povidone iodine activity against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecalis using a surface test [J].

Block, C ;

Robenshtok, E ;

Simhon, A ;

Shapiro, M .

JOURNAL OF HOSPITAL INFECTION, 2000, 46 (02) :147-152

[5] Triclosan resistance in methicillin-resistant Staphylococcus aureus (MRSA) [J].

Brenwald, NP ;

Fraise, AP .

JOURNAL OF HOSPITAL INFECTION, 2003, 55 (02) :141-144

[6] Antimicrobial and toxicological profile of the new biocide Akacid plus® [J].

Buxbaum, Astrid ;

Kratzer, Christina ;

Graninger, Wolfgang ;

Georgopoulos, Apostolos .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2006, 58 (01) :193-197

[7]

Caelli M, 2000, J HOSP INFECT, V46, P236, DOI [10.1053/jhin.2000.0830, 10.1016/S0195-6701(00)90830-2]

[8] Double-blind, randomized, placebo-controlled study of a lotion containing triethyl citrate and ethyl linoleate in the treatment of acne vulgaris [J].

Charakida, A. ;

Charakida, M. ;

Chu, A. C. .

BRITISH JOURNAL OF DERMATOLOGY, 2007, 157 (03) :569-574

[9] A randomized, double-blind comparison of a clindamycin phosphate/benzoyl peroxide gel formulation and a matching clindamycin gel with respect to microbiologic activity and clinical efficacy in the topical treatment of acne vulgaris [J].

Cunliffe, WJ ;

Holland, KT ;

Bojar, R ;

Levy, SF .

CLINICAL THERAPEUTICS, 2002, 24 (07) :1117-1133

[10] Effectiveness of topical antibiotics on Staphylococcus aureus biofilm in vitro [J].

Desrosiers, Martin ;

Bendouah, Zohra ;

Barbeau, Jean .

AMERICAN JOURNAL OF RHINOLOGY, 2007, 21 (02) :149-153

← 1 2 3 4 5 6 7 →