Neurofibromatosis 2: Loss of merlin's protective spell

被引：43

作者：

Gusella, JF

Ramesh, V

MacCollin, M

Jacoby, LB

机构：

[1] Molecular Neurogenetics Unit, Massachusetts General Hospital East, Charlestown

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1996年 / 6卷 / 01期

关键词：

D O I：

10.1016/S0959-437X(96)90016-7

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Schwannomas and meningiomas occur as multiple tumors in sufferers of neurofibromatosis 2 (NF2) and as solitary tumors in the general population due to the inactivation of a gene at chromosome 22q12. In 1993, a location cloning approach revealed this tumor suppressor, dubbed merlin, as a novel member of a family of proteins that link elements of the cytoskeleton and the cell membrane. Subsequent investigations have confirmed merlin's role in tumor formation, but have yet to reveal its mechanism of action.

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页码：87 / 92

页数：6

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