共 101 条
Caspase-independent cell death: leaving the set without the final cut
被引:292
作者:

Tait, S. W. G.
论文数: 0 引用数: 0
h-index: 0
机构:
St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA

Green, D. R.
论文数: 0 引用数: 0
h-index: 0
机构:
St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA
机构:
[1] St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA
来源:
关键词:
caspases;
mitochondria;
caspase-independent cell death;
mitochondrial outer membrane permeabilization;
cancer;
D O I:
10.1038/onc.2008.311
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
Apoptosis is dependent upon caspase activation leading to substrate cleavage and, ultimately, cell death. Although required for the apoptotic phenotype, it has become apparent that cells frequently die even when caspase function is blocked. This process, termed caspase-independent cell death (CICD), occurs in response to most intrinsic apoptotic cues, provided that mitochondrial outer membrane permeabilization has occurred. Death receptor ligation can also trigger a form of CICD termed necroptosis. In this review, we will examine the molecular mechanisms governing CICD, highlight recent findings demonstrating recovery from conditions of CICD and discuss potential pathophysiological functions of these processes.
引用
收藏
页码:6452 / 6461
页数:10
相关论文
共 101 条
[1]
A morphologically conserved nonapoptotic program promotes linker cell death in Caenorhabditis elegans
[J].
Abraham, Mary C.
;
Lu, Yun
;
Shaham, Shai
.
DEVELOPMENTAL CELL,
2007, 12 (01)
:73-86

Abraham, Mary C.
论文数: 0 引用数: 0
h-index: 0
机构:
Rockefeller Univ, Lab Dev Genet, New York, NY 10021 USA Rockefeller Univ, Lab Dev Genet, New York, NY 10021 USA

Lu, Yun
论文数: 0 引用数: 0
h-index: 0
机构:
Rockefeller Univ, Lab Dev Genet, New York, NY 10021 USA Rockefeller Univ, Lab Dev Genet, New York, NY 10021 USA

Shaham, Shai
论文数: 0 引用数: 0
h-index: 0
机构:
Rockefeller Univ, Lab Dev Genet, New York, NY 10021 USA Rockefeller Univ, Lab Dev Genet, New York, NY 10021 USA
[2]
Mitochondrial release of AIF and EndoG requires caspase activation downstream of Bax/Bak-mediated permeabilization
[J].
Arnoult, D
;
Gaume, B
;
Karbowski, M
;
Sharpe, JC
;
Cecconi, F
;
Youle, RJ
.
EMBO JOURNAL,
2003, 22 (17)
:4385-4399

Arnoult, D
论文数: 0 引用数: 0
h-index: 0
机构: NINDS, Biochem Sect, Surg Neurol Branch, NIH, Bethesda, MD 20892 USA

Gaume, B
论文数: 0 引用数: 0
h-index: 0
机构: NINDS, Biochem Sect, Surg Neurol Branch, NIH, Bethesda, MD 20892 USA

Karbowski, M
论文数: 0 引用数: 0
h-index: 0
机构: NINDS, Biochem Sect, Surg Neurol Branch, NIH, Bethesda, MD 20892 USA

Sharpe, JC
论文数: 0 引用数: 0
h-index: 0
机构: NINDS, Biochem Sect, Surg Neurol Branch, NIH, Bethesda, MD 20892 USA

Cecconi, F
论文数: 0 引用数: 0
h-index: 0
机构: NINDS, Biochem Sect, Surg Neurol Branch, NIH, Bethesda, MD 20892 USA

Youle, RJ
论文数: 0 引用数: 0
h-index: 0
机构:
NINDS, Biochem Sect, Surg Neurol Branch, NIH, Bethesda, MD 20892 USA NINDS, Biochem Sect, Surg Neurol Branch, NIH, Bethesda, MD 20892 USA
[3]
Mitochondrial fragmentation in apoptosis
[J].
Arnoult, Damien
.
TRENDS IN CELL BIOLOGY,
2007, 17 (01)
:6-12

Arnoult, Damien
论文数: 0 引用数: 0
h-index: 0
机构:
Inst Pasteur, Unite Physiopathol Infect Lentivirales, F-75724 Paris 15, France Inst Pasteur, Unite Physiopathol Infect Lentivirales, F-75724 Paris 15, France
[4]
Switch from caspase-dependent to caspase-independent death during heart development - Essential role of endonuclease G in ischemia-induced DNA processing of differentiated cardiomyocytes
[J].
Bahi, Nuria
;
Zhang, Jisheng
;
Llovera, Marta
;
Ballester, Manel
;
Comella, Joan X.
;
Sanchis, Daniel
.
JOURNAL OF BIOLOGICAL CHEMISTRY,
2006, 281 (32)
:22943-22952

Bahi, Nuria
论文数: 0 引用数: 0
h-index: 0
机构:
UdL, HUAV,Dept CMB, Lab Invest, Cell Signaling & Apoptosis Grp, Lleida 25198, Spain UdL, HUAV,Dept CMB, Lab Invest, Cell Signaling & Apoptosis Grp, Lleida 25198, Spain

Zhang, Jisheng
论文数: 0 引用数: 0
h-index: 0
机构:
UdL, HUAV,Dept CMB, Lab Invest, Cell Signaling & Apoptosis Grp, Lleida 25198, Spain UdL, HUAV,Dept CMB, Lab Invest, Cell Signaling & Apoptosis Grp, Lleida 25198, Spain

Llovera, Marta
论文数: 0 引用数: 0
h-index: 0
机构:
UdL, HUAV,Dept CMB, Lab Invest, Cell Signaling & Apoptosis Grp, Lleida 25198, Spain UdL, HUAV,Dept CMB, Lab Invest, Cell Signaling & Apoptosis Grp, Lleida 25198, Spain

Ballester, Manel
论文数: 0 引用数: 0
h-index: 0
机构:
UdL, HUAV,Dept CMB, Lab Invest, Cell Signaling & Apoptosis Grp, Lleida 25198, Spain UdL, HUAV,Dept CMB, Lab Invest, Cell Signaling & Apoptosis Grp, Lleida 25198, Spain

Comella, Joan X.
论文数: 0 引用数: 0
h-index: 0
机构:
UdL, HUAV,Dept CMB, Lab Invest, Cell Signaling & Apoptosis Grp, Lleida 25198, Spain UdL, HUAV,Dept CMB, Lab Invest, Cell Signaling & Apoptosis Grp, Lleida 25198, Spain

Sanchis, Daniel
论文数: 0 引用数: 0
h-index: 0
机构:
UdL, HUAV,Dept CMB, Lab Invest, Cell Signaling & Apoptosis Grp, Lleida 25198, Spain UdL, HUAV,Dept CMB, Lab Invest, Cell Signaling & Apoptosis Grp, Lleida 25198, Spain
[5]
Caspase-3 inhibition preserves myocardial geometry and long-term function after infarction
[J].
Balsam, LB
;
Kofidis, T
;
Robbins, RC
.
JOURNAL OF SURGICAL RESEARCH,
2005, 124 (02)
:194-200

Balsam, LB
论文数: 0 引用数: 0
h-index: 0
机构:
Stanford Univ, Sch Med, Dept Cardiothorac Surg, Stanford, CA 94305 USA Stanford Univ, Sch Med, Dept Cardiothorac Surg, Stanford, CA 94305 USA

Kofidis, T
论文数: 0 引用数: 0
h-index: 0
机构:
Stanford Univ, Sch Med, Dept Cardiothorac Surg, Stanford, CA 94305 USA Stanford Univ, Sch Med, Dept Cardiothorac Surg, Stanford, CA 94305 USA

Robbins, RC
论文数: 0 引用数: 0
h-index: 0
机构:
Stanford Univ, Sch Med, Dept Cardiothorac Surg, Stanford, CA 94305 USA Stanford Univ, Sch Med, Dept Cardiothorac Surg, Stanford, CA 94305 USA
[6]
Growth arrest and autophagy are required for salivary gland cell degradation in Drosophila
[J].
Berry, Deborah L.
;
Baehrecke, Eric H.
.
CELL,
2007, 131 (06)
:1137-1148

Berry, Deborah L.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Maryland, Inst Biotechnol, Ctr Biosyst Res, College Pk, MD 20742 USA Univ Maryland, Inst Biotechnol, Ctr Biosyst Res, College Pk, MD 20742 USA

Baehrecke, Eric H.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Maryland, Inst Biotechnol, Ctr Biosyst Res, College Pk, MD 20742 USA
Univ Massachusetts, Sch Med, Dept Canc Biol, Worcester, MA 01605 USA Univ Maryland, Inst Biotechnol, Ctr Biosyst Res, College Pk, MD 20742 USA
[7]
Protection from brain damage and bacterial infection in murine stroke by the novel caspase-inhibitor Q-VD-OPH
[J].
Braun, Johann Sebastian
;
Prass, Konstantin
;
Dirnagl, Ulrich
;
Meisel, Andreas
;
Meisel, Christian
.
EXPERIMENTAL NEUROLOGY,
2007, 206 (02)
:183-191

Braun, Johann Sebastian
论文数: 0 引用数: 0
h-index: 0
机构: United Arab Emirates Univ, Fac Med & Hlth Sci, Dept Internal Med, Div Neurol, Al Ain, U Arab Emirates

Prass, Konstantin
论文数: 0 引用数: 0
h-index: 0
机构: United Arab Emirates Univ, Fac Med & Hlth Sci, Dept Internal Med, Div Neurol, Al Ain, U Arab Emirates

Dirnagl, Ulrich
论文数: 0 引用数: 0
h-index: 0
机构: United Arab Emirates Univ, Fac Med & Hlth Sci, Dept Internal Med, Div Neurol, Al Ain, U Arab Emirates

Meisel, Andreas
论文数: 0 引用数: 0
h-index: 0
机构: United Arab Emirates Univ, Fac Med & Hlth Sci, Dept Internal Med, Div Neurol, Al Ain, U Arab Emirates

Meisel, Christian
论文数: 0 引用数: 0
h-index: 0
机构: United Arab Emirates Univ, Fac Med & Hlth Sci, Dept Internal Med, Div Neurol, Al Ain, U Arab Emirates
[8]
Loss of Aif function causes cell death in the mouse embryo, but the temporal progression of patterning is normal
[J].
Brown, Doris
;
Yu, Benjamin D.
;
Joza, Nicholas
;
Benit, Paule
;
Meneses, Juanito
;
Firpo, Meri
;
Rustin, Pierre
;
Penninger, Josef M.
;
Martin, Gail R.
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
2006, 103 (26)
:9918-9923

Brown, Doris
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Francisco, Dept Anat, San Francisco, CA 94143 USA

Yu, Benjamin D.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Francisco, Dept Anat, San Francisco, CA 94143 USA

Joza, Nicholas
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Francisco, Dept Anat, San Francisco, CA 94143 USA

Benit, Paule
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Francisco, Dept Anat, San Francisco, CA 94143 USA

Meneses, Juanito
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Francisco, Dept Anat, San Francisco, CA 94143 USA

Firpo, Meri
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Francisco, Dept Anat, San Francisco, CA 94143 USA

Rustin, Pierre
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Francisco, Dept Anat, San Francisco, CA 94143 USA

Penninger, Josef M.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Francisco, Dept Anat, San Francisco, CA 94143 USA

Martin, Gail R.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Anat, San Francisco, CA 94143 USA Univ Calif San Francisco, Dept Anat, San Francisco, CA 94143 USA
[9]
Caspase inhibition causes hyperacute tumor necrosis factor-induced shock via oxidative stress and phospholipase A2
[J].
Cauwels, A
;
Janssen, B
;
Waeytens, A
;
Cuvelier, C
;
Brouckaert, P
.
NATURE IMMUNOLOGY,
2003, 4 (04)
:387-393

Cauwels, A
论文数: 0 引用数: 0
h-index: 0
机构: State Univ Ghent, Dept Mol Biomed Res, Mol Pathophysiol & Expt Therapy Unit, B-9000 Ghent, Belgium

Janssen, B
论文数: 0 引用数: 0
h-index: 0
机构: State Univ Ghent, Dept Mol Biomed Res, Mol Pathophysiol & Expt Therapy Unit, B-9000 Ghent, Belgium

Waeytens, A
论文数: 0 引用数: 0
h-index: 0
机构: State Univ Ghent, Dept Mol Biomed Res, Mol Pathophysiol & Expt Therapy Unit, B-9000 Ghent, Belgium

Cuvelier, C
论文数: 0 引用数: 0
h-index: 0
机构: State Univ Ghent, Dept Mol Biomed Res, Mol Pathophysiol & Expt Therapy Unit, B-9000 Ghent, Belgium

Brouckaert, P
论文数: 0 引用数: 0
h-index: 0
机构: State Univ Ghent, Dept Mol Biomed Res, Mol Pathophysiol & Expt Therapy Unit, B-9000 Ghent, Belgium
[10]
Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development
[J].
Cecconi, F
;
Alvarez-Bolado, G
;
Meyer, BI
;
Roth, KA
;
Gruss, P
.
CELL,
1998, 94 (06)
:727-737

Cecconi, F
论文数: 0 引用数: 0
h-index: 0
机构: Max Planck Inst Biophys Chem, Dept Mol Cell Biol, D-37077 Gottingen, Germany

Alvarez-Bolado, G
论文数: 0 引用数: 0
h-index: 0
机构: Max Planck Inst Biophys Chem, Dept Mol Cell Biol, D-37077 Gottingen, Germany

Meyer, BI
论文数: 0 引用数: 0
h-index: 0
机构: Max Planck Inst Biophys Chem, Dept Mol Cell Biol, D-37077 Gottingen, Germany

Roth, KA
论文数: 0 引用数: 0
h-index: 0
机构: Max Planck Inst Biophys Chem, Dept Mol Cell Biol, D-37077 Gottingen, Germany

Gruss, P
论文数: 0 引用数: 0
h-index: 0
机构:
Max Planck Inst Biophys Chem, Dept Mol Cell Biol, D-37077 Gottingen, Germany Max Planck Inst Biophys Chem, Dept Mol Cell Biol, D-37077 Gottingen, Germany