White Matter Hyperintensities Relate to Clinical Progression in Subjective Cognitive Decline

被引：80

作者：

Benedictus, Marije R. ^{[1
,2
]}

van Harten, Argonde C. ^{[1
,2
]}

Leeuwis, Annebet E. ^{[1
,2
]}

Koene, Teddy ^{[4
]}

Scheltens, Philip ^{[1
,2
]}

Barkhof, Frederik ^{[3
]}

Prins, Niels D. ^{[1
,2
]}

van der Flier, Wiesje M. ^{[1
,2
,5
]}

机构：

[1] Vrije Univ Amsterdam, Med Ctr, Alzheimer Ctr, Amsterdam, Netherlands

[2] Vrije Univ Amsterdam, Med Ctr, Dept Neurol, Amsterdam, Netherlands

[3] Vrije Univ Amsterdam, Med Ctr, Dept Radiol & Nucl Med, Amsterdam, Netherlands

[4] Vrije Univ Amsterdam, Med Ctr, Dept Med Psychol, Amsterdam, Netherlands

[5] Vrije Univ Amsterdam, Med Ctr, Dept Epidemiol & Biostat, Amsterdam, Netherlands

来源：

STROKE | 2015年 / 46卷 / 09期

关键词：

cognitive decline; small vessel disease; subjective complaints; vascular cognitive impairment; white matter lesions; SMALL-VESSEL DISEASE; ALZHEIMERS-DISEASE; CEREBROVASCULAR-DISEASE; DEMENTIA; IMPAIRMENT; ASSOCIATION; CARE;

D O I：

10.1161/STROKEAHA.115.009475

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background and Purpose-In patients with subjective cognitive decline, we assessed whether small vessel disease was associated with clinical progression and cognitive decline. Methods-We included 334 patients with subjective cognitive decline. Follow-up was 3+/-2 years. Results-Fifty-three (16%) patients progressed clinically to mild cognitive impairment or dementia. White matter hyperintensities were associated with clinical progression and with annual decline on memory, attention, executive functioning, and global cognition. Microbleeds and lacunes were not associated with clinical progression or cognitive decline. Conclusions-In patients with subjective cognitive decline, patients with white matter hyperintensities are at increased risk of clinical progression and cognitive decline.

引用

页码：2661 / 2664

页数：4

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