Translocations in solid tumours

被引：18

作者：

Cooper, CS

机构：

[1] Haddow Laboratories, Sutton, Surrey SM2 5NG

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1996年 / 6卷 / 01期

关键词：

D O I：

10.1016/S0959-437X(96)90013-1

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Specific chromosomal translocations have now been identified in a variety of solid tumour types. Recent developments in this field include the identification of novel genes involved in the t(X;18) synovial sarcoma translocation and the discovery that the high-mobility group protein gene, HMGI-C, is involved in the chromosome 12 rearrangements found in lipomas and uterine leiomyomas. These discoveries may have important implications for the strategies used in tumour diagnosis and treatment.

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页码：71 / 75

页数：5

相关论文

共 26 条

[1]

ASHAR HR, 1995, CELL, V82, P57

[2] REARRANGEMENT OF THE PAX3 PAIRED BOX GENE IN THE PEDIATRIC SOLID TUMOR ALVEOLAR RHABDOMYOSARCOMA [J].

BARR, FG ;

GALILI, N ;

HOLICK, J ;

BIEGEL, JA ;

ROVERA, G ;

EMANUEL, BS .

NATURE GENETICS, 1993, 3 (02) :113-117

[3] MOLECULAR ASSAYS FOR CHROMOSOMAL TRANSLOCATIONS IN THE DIAGNOSIS OF PEDIATRIC SOFT-TISSUE SARCOMAS [J].

BARR, FG ;

CHATTEN, J ;

DCRUZ, CM ;

WILSON, AE ;

NAUTA, LE ;

NYCUM, LM ;

BIEGEL, JA ;

WORNER, RB .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1995, 273 (07) :553-557

[4] THE RHOMBOTIN FAMILY OF CYSTEINE-RICH LIM-DOMAIN ONCOGENES - DISTINCT MEMBERS ARE INVOLVED IN T-CELL TRANSLOCATIONS TO HUMAN CHROMOSOME-11P15 AND CHROMOSOME-11P13 [J].

BOEHM, T ;

FORONI, L ;

KANEKO, Y ;

PERUTZ, MF ;

RABBITTS, TH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (10) :4367-4371

[5] IDENTIFICATION OF NOVEL GENES, SYT AND SSX, INVOLVED IN THE T(X18)(P11.2Q11.2) TRANSLOCATION FOUND IN HUMAN SYNOVIAL SARCOMA [J].

CLARK, J ;

ROCQUES, PJ ;

CREW, AJ ;

GILL, S ;

SHIPLEY, J ;

CHAN, AML ;

GUSTERSON, BA ;

COOPER, CS .

NATURE GENETICS, 1994, 7 (04) :502-508

[6] FUSION OF SYT TO 2 GENES, SSX1 AND SSX2, ENCODING PROTEINS WITH HOMOLOGY TO THE KRUPPEL-ASSOCIATED BOX IN HUMAN SYNOVIAL SARCOMA [J].

CREW, AJ ;

CLARK, J ;

FISHER, C ;

GILL, S ;

GRIMER, R ;

MITCHELL, P ;

CHAND, A ;

SHIPLEY, J ;

GUSTERSON, BA ;

COOPER, CS .

EMBO JOURNAL, 1995, 14 (10) :2333-2340

[7] FUSION OF CHOP TO A NOVEL RNA-BINDING PROTEIN IN HUMAN MYXOID LIPOSARCOMA [J].

CROZAT, A ;

AMAN, P ;

MANDAHL, N ;

RON, D .

NATURE, 1993, 363 (6430) :640-644

[8]

DAVIS RJ, 1994, CANCER RES, V54, P2869

[9] DISTINCT XP11.2 BREAKPOINT REGIONS IN SYNOVIAL SARCOMA REVEALED BY METAPHASE AND INTERPHASE FISH - RELATIONSHIP TO HISTOLOGIC SUBTYPES [J].

DELEEUW, B ;

SUIJKERBUIJK, RF ;

WEGHUIS, DO ;

MELONI, AM ;

STENMAN, G ;

KINDBLOM, LG ;

BALEMANS, M ;

VANDENBERG, E ;

MOLENAAR, WM ;

SANDBERG, AA ;

VANKESSEL, AG .

CANCER GENETICS AND CYTOGENETICS, 1994, 73 (02) :89-94

[10] THE PML-RAR-ALPHA FUSION MESSENGER-RNA GENERATED BY THE T(15-17) TRANSLOCATION IN ACUTE PROMYELOCYTIC LEUKEMIA ENCODES A FUNCTIONALLY ALTERED RAR [J].

DETHE, H ;

LAVAU, C ;

MARCHIO, A ;

CHOMIENNE, C ;

DEGOS, L ;

DEJEAN, A .

CELL, 1991, 66 (04) :675-684