HPV16 transmission between a couple with HPV-related head and neck cancer

被引：34

作者：

Haddad, Robert ^{[1
]}

Crum, Christopher ^{[2
]}

Chen, Zigui ^{[3
]}

Krane, Jeffrey ^{[2
]}

Posner, Marshall ^{[1
]}

Li, Yi ^{[4
]}

Burk, Robert ^{[3
]}

机构：

[1] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

[2] Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA

[3] Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10461 USA

[4] Dana Farber Canc Inst, Dept Biostat & Computat Biol, Boston, MA 02115 USA

来源：

ORAL ONCOLOGY | 2008年 / 44卷 / 08期

关键词：

human papillomavirus 16; head and neck cancer;

D O I：

10.1016/j.oraloncology.2007.09.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Although squamous cell carcinoma of the head and neck (SCCHN) is closely linked to tobacco and alcohol. use, there is an increasing incidence HPV16-related SCCHN arising in the oropharynx. The mechanisms of viral transmission, carcinogenesis and natural history are not welt understood. Here, we report a couple-husband and wife diagnosed synchronously with squamous cell carcinoma of the head and neck wherein the tumors were positive for HPV16 by PCR diagnosis. Both viral genomes were genetically identical and closely related to the revised European prototype, HPV16R. An uncommon signal variant nucleotide was identified in both genomes that is not present in the HPV16R. These tumors likely represent transmission between the couple. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：812 / 815

页数：4

共 21 条

[1]

Ault K. A., 2006, Infectious Diseases in Obstetrics and Gynecology, V13, P1, DOI 10.1155/IDOG/2006/40470

[2] Concordance of specific human papillomavirus types in sex partners is more prevalent than would be expected by chance and is associated with increased viral loads [J].