How to find a prognostic biomarker for progressive diabetic nephropathy

被引：13

作者：

Brosius, Frank C. ^{[1
,2
]}

Pennathur, Subramaniam ^{[1
]}

机构：

[1] Univ Michigan, Med Ctr, Dept Internal Med, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Sch Med, Dept Mol & Integrat Physiol, Ann Arbor, MI USA

来源：

KIDNEY INTERNATIONAL | 2013年 / 83卷 / 06期

关键词：

TNF RECEPTORS 1; URINARY PROTEOMICS; RENAL-FUNCTION; CKD;

D O I：

10.1038/ki.2013.58

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

As a prognostic biomarker for progression of diabetic nephropathy, albuminuria fails in terms of sensitivity and specificity. Better urinary or plasma biomarkers are needed that can predict which diabetic patients are at highest risk for progression. Bhensdadia et al. report proteomic investigations that identified urinary haptoglobin as a potential prognostic biomarker for progressive diabetic nephropathy. Although as a single marker urinary haptoglobin adds little to albuminuria, together the two appear to provide better diagnostic accuracy than albuminuria alone.

引用

页码：996 / 998

页数：3

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