NKT cells - conductors of tumor immunity?

被引：240

作者：

Smyth, MJ

Crowe, NY

Hayakawa, Y

Takeda, K

Yagita, H

Godfrey, DI

机构：

[1] Peter MacCallum Canc Inst, Trescowthick Labs, Melbourne, Vic 3002, Australia

[2] Monash Univ Sch Med, Dept Pathol & Immunol, Prahran, Vic 3181, Australia

[3] Juntendo Univ, Sch Med, Dept Immunol, Bunkyo Ku, Tokyo 1138421, Japan

来源：

CURRENT OPINION IN IMMUNOLOGY | 2002年 / 14卷 / 02期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S0952-7915(02)00316-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

NKT cells are key players in the regulation of antitumor immunity, particularly in experimental models of tumor immunotherapy, such as IL-12 or alpha-galactosylceramide administration. They may also operate in natural antitumor immunity. NKT cells are best known for their immunosuppressive functions; however, NKT cells interact with a range of other cell types (particularly dendritic cells and NK cells) and the outcome of NKT-cell stimulation depends on these and on the cytokine/co-stimulatory milieu.

引用

页码：165 / 171

页数：7

共 66 条

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