Rhythmic expression of RORβ mRNA in the mice suprachiasmatic nucleus

被引：23

作者：

Sumi, Y

Yagita, K

Yamaguchi, S

Ishida, Y

Kuroda, Y

Okamura, H

机构：

[1] Kobe Univ, Grad Sch Med, Dept Brain Sci, Div Mol Brain Sci,Chuo Ku, Kobe, Hyogo 6500017, Japan

[2] Kobe Univ, Grad Sch Med, Dept Appl Mol Med, Div Gasterointestinal Surg, Kobe, Hyogo 6500017, Japan

来源：

NEUROSCIENCE LETTERS | 2002年 / 320卷 / 1-2期

关键词：

circadian rhythm; retinoid-related orphan receptor beta; suprachiasmatic nucleus; cerebral cortex; mouse;

D O I：

10.1016/S0304-3940(02)00011-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The expression of the brain rich orphan nuclear receptor RORbeta (retinoid-related orphan receptor beta) was investigated in the mouse brain by in situ hybridization using antisense cRNA probe. Positive RORbeta mRNA signals were detected in various parts of the brain with high expression in the suprachiasmatic nucleus (SCN). In the SCN, RORbeta mRNA signals showed a peak at early daytime (ZT/CT4) and a trough at early nighttime (ZT/CT16) in both light-dark and constant dark conditions. Light exposure at subjective night did not alter the expression level. These findings suggest that RORbeta is a new member of a transcription factor possibly related to the circadian pacemaking system. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：13 / 16

页数：4

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