Water-triggered and gold(I)-catalyzed cascade addition/cyclization of terminal alkynes with ortho-alkynylaryl aidehyde

被引：175

作者：

Yao, XQ ^{[1
]}

Li, CJ ^{[1
]}

机构：

[1] McGill Univ, Dept Chem, Montreal, PQ H3A 2K6, Canada

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 09期

关键词：

D O I：

10.1021/ol060645p

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly efficient alkynylation-cyclization of terminal alkynes with ortho-alkynylaryl aldehydes leading to 1-alkynyl-1H-isochromenes was developed by using a gold-phosphine complex as catalyst in water. The reaction was dually promoted by an electron-donating phosphine ligand and water and was chelation-controlled.

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页码：1953 / 1955

页数：3

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