Variation in response of human skin to irritant challenge

被引：57

作者：

Judge, MR

Griffiths, HA

Basketter, DA

White, IR

Rycroft, RJG

McFadden, JP

机构：

[1] ST THOMAS HOSP, ST JOHNS INST DERMATOL, LONDON SE1 7EH, ENGLAND

[2] UNILEVER RES, ENVIRONM SAFETY LAB, SHARNBROOK MK44 1LQ, BEDS, ENGLAND

来源：

CONTACT DERMATITIS | 1996年 / 34卷 / 02期

关键词：

irritant contact dermatitis; sodium lauryl sulfate; human in vivo testing; patch test; interindividual variation; Draize rabbit skin irritation test;

D O I：

10.1111/j.1600-0536.1996.tb02141.x

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

A major obstacle to the establishment of a protocol for in vivo irritant skin testing in humans is the apparent variability of responses between individuals. This study of the threshold response of normal human skin to a standard irritant (sodium lauryl sulfate 0.3-10%), in a group of 22 subjects, revealed a marked interindividual variation in their threshold reaction. The results demonstrate that this phenomenon does exist and that it will have to be allowed for in future human irritant test systems or assays. (C) Munksgaard, 1996.

引用

页码：115 / 117

页数：3

共 12 条

[1] THE IDENTIFICATION AND CLASSIFICATION OF SKIN IRRITATION HAZARD BY A HUMAN PATCH TEST [J].