Taking polycation gene delivery systems from in vitro to in vivo

被引：161

作者：

Kabanov, AV ^{[1
]}

机构：

[1] Univ Nebraska, Coll Pharm, Dept Pharmaceut Sci, Nebraska Med Ctr 986025, Omaha, NE 68198 USA

来源：

PHARMACEUTICAL SCIENCE & TECHNOLOGY TODAY | 1999年 / 2卷 / 09期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/S1461-5347(99)00186-8

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

It is widely believed that non-viral gene delivery systems may improve safety and overcome tissue-tropism limitations associated with viral-based gene therapies. Cationic liposome-based gene delivery currently accounts for 9-12% of ongoing gene therapy clinical trials in the United States and Europe. Polycation-based gene delivery is at an earlier development stage. However, both in vitro and in vivo studies have demonstrated that this is an area of much promise. Complexes of polycations with DNA result in major improvements in the control of size, charge, and the hydrophillic-lipophilic characteristics of the transfecting species, when compared with other non-viral systems. This review serves as an introduction to the current status of this field.

引用

页码：365 / 372

页数：8

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