Vatairea macrocarpa lectin induces paw edema with leukocyte infiltration

被引：30

作者：

Alencar, NMN

Assreuy, AMS

Criddle, DN

Souza, EP

Soares, PMG

Havt, A

Aragao, KS

Bezerra, DP

Ribeiro, RA

Cavada, BS

机构：

[1] Univ Fed Ceara, Fac Med, Dept Fisiol & Farmacol, BR-60430270 Fortaleza, Ceara, Brazil

[2] Univ Fed Ceara, CCS, Mestrado Acad Ciencias Fisiol, BR-60430270 Fortaleza, Ceara, Brazil

来源：

PROTEIN AND PEPTIDE LETTERS | 2004年 / 11卷 / 02期

关键词：

paw edema; leukocyte infiltration; Vatairea macrocarpa lectin;

D O I：

10.2174/0929866043478284

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

A lectin from Vatairea macrocarpa (Vmac) seeds was investigated in a model of paw edema in rats and the possible involvement of leukocytes. Vmac (200 and 400 mug/paw, s.c.) induced a significant time- and dose-dependent paw edema, with leukocyte infiltration, which was drastically reduced in leukopaenic animals. These data suggest a pro-inflammatory effect for this lectin that is dependent on the presence of leukocytes.

引用

收藏

页码：195 / 200

页数：6

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