Distributed Medical Image Analysis and Diagnosis through Crowd-Sourced Games: A Malaria Case Study

被引:81
作者
Mavandadi, Sam [1 ]
Dimitrov, Stoyan [1 ]
Feng, Steve [1 ]
Yu, Frank [1 ]
Sikora, Uzair [1 ]
Yaglidere, Oguzhan [1 ]
Padmanabhan, Swati [1 ]
Nielsen, Karin [2 ]
Ozcan, Aydogan [1 ,3 ,4 ,5 ]
机构
[1] Univ Calif Los Angeles, Dept Elect Engn, Los Angeles, CA 90024 USA
[2] Univ Calif Los Angeles, Sch Med, Dept Pediat, Div Infect Dis, Los Angeles, CA 90024 USA
[3] Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA USA
[4] Univ Calif Los Angeles, Calif NanoSyst Inst, Los Angeles, CA USA
[5] Univ Calif Los Angeles, Sch Med, Dept Surg, Los Angeles, CA 90024 USA
来源
PLOS ONE | 2012年 / 7卷 / 05期
关键词
D O I
10.1371/journal.pone.0037245
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
In this work we investigate whether the innate visual recognition and learning capabilities of untrained humans can be used in conducting reliable microscopic analysis of biomedical samples toward diagnosis. For this purpose, we designed entertaining digital games that are interfaced with artificial learning and processing back-ends to demonstrate that in the case of binary medical diagnostics decisions (e. g., infected vs. uninfected), with the use of crowd-sourced games it is possible to approach the accuracy of medical experts in making such diagnoses. Specifically, using non-expert gamers we report diagnosis of malaria infected red blood cells with an accuracy that is within 1.25% of the diagnostics decisions made by a trained medical professional.
引用
收藏
页数:8
相关论文
共 28 条
[1]   The use of computer games as an educational tool: identification of appropriate game types and game elements [J].
Amory, A ;
Naicker, K ;
Vincent, J ;
Adams, C .
BRITISH JOURNAL OF EDUCATIONAL TECHNOLOGY, 1999, 30 (04) :311-321
[2]   Mission Impact: Role of Protection of Information Systems [J].
Anderson, Evan ;
Choobineh, Joobin ;
Fazen, Michael ;
Grimaila, Michael .
PROCEEDINGS OF THE 5TH INTERNATIONAL CONFERENCE ON INFORMATION WARFARE AND SECURITY, 2010, :1-15
[3]  
[Anonymous], 2006, Elements of Information Theory
[4]   Holographic pixel super-resolution in portable lensless on-chip microscopy using a fiber-optic array [J].
Bishara, Waheb ;
Sikora, Uzair ;
Mudanyali, Onur ;
Su, Ting-Wei ;
Yaglidere, Oguzhan ;
Luckhart, Shirley ;
Ozcan, Aydogan .
LAB ON A CHIP, 2011, 11 (07) :1276-1279
[5]   Mobile Phone Based Clinical Microscopy for Global Health Applications [J].
Breslauer, David N. ;
Maamari, Robi N. ;
Switz, Neil A. ;
Lam, Wilbur A. ;
Fletcher, Daniel A. .
PLOS ONE, 2009, 4 (07)
[6]   Predicting protein structures with a multiplayer online game [J].
Cooper, Seth ;
Khatib, Firas ;
Treuille, Adrien ;
Barbero, Janos ;
Lee, Jeehyung ;
Beenen, Michael ;
Leaver-Fay, Andrew ;
Baker, David ;
Popovic, Zoran ;
Players, Foldit .
NATURE, 2010, 466 (7307) :756-760
[7]  
Cooper Seth., 2010, Proceedings of the Fifth International Conference on the Foundations of Digital Games, FDG '10, P40, DOI DOI 10.1145/1822348.1822354
[8]   A semi-automatic method for quantification and classification of erythrocytes infected with malaria parasites in microscopic images [J].
Diaz, Gloria ;
Gonzalez, Fabio A. ;
Romero, Eduardo .
JOURNAL OF BIOMEDICAL INFORMATICS, 2009, 42 (02) :296-307
[9]   Crowdsourcing and Attention [J].
Huberman, Bernardo A. .
COMPUTER, 2008, 41 (11) :103-105
[10]  
Kafai Y.B., 2006, Games And Culture: A Journal Of Interactive Media, V1, P36, DOI DOI 10.1177/1555412005281767