Protective effect of a marine polyphenol, dieckol against carbon tetrachloride-induced acute liver damage in mouse

被引：57

作者：

Kang, Min-Cheol ^{[1
]}

Kang, Sung-Myung ^{[1
]}

Ahn, Ginnae ^{[2
]}

Kim, Kil-Nam ^{[3
]}

Kang, Nalae ^{[1
]}

Samarakoon, Kalpa W. ^{[1
]}

Oh, Myung-Cheol ^{[4
]}

Lee, Jung-Suck ^{[5
]}

Jeon, You-Jin ^{[1
,6
]}

机构：

[1] Jeju Natl Univ, Dept Marine Life Sci, Cheju 690756, South Korea

[2] Tokyo Univ Agri & Technol, Inst Agr, Div Anim Life Sci, Tokyo, Japan

[3] KBSI, Jeju Ctr, Cheju, South Korea

[4] Jeju Int Univ, Dept Food Sci & Food Serv Ind, Cheju 690714, South Korea

[5] Jeju Natl Univ, Ind Acad Cooperat Fdn, Cheju 690756, South Korea

[6] Aqua Green Technol Co Ltd, Jeju Bioind Ctr 209, Cheju 690121, South Korea

来源：

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY | 2013年 / 35卷 / 03期

关键词：

Carbon tetrachloride (CCl4); Ecklonia cava; Dieckol; Liver; Hepato-protetive effect; Phlorotannins; MEDIATED HEPATIC APOPTOSIS; INDUCED OXIDATIVE STRESS; LIPID-PEROXIDATION; ECKLONIA-CAVA; BROWN ALGA; ANTIOXIDANT; CCL4; PHLOROTANNINS; EXTRACT; SERUM;

D O I：

10.1016/j.etap.2013.02.013

中图分类号：

X [环境科学、安全科学];

学科分类号：

083001 [环境科学];

摘要：

In this study, the hepatoprotective effect of dieckol on carbon tetrachloride (CCl4) induced hepatic damages in ICR mice liver was investigated. Mice were randomly divided into 4 groups such as saline treated (negative control), CCl4 treated (positive control), CCl4 + dieckol (5 mg/kg mouse) and CCl4 + dieckol (25 mg/kg mouse), respectively. The body weights and survival rates of mice, followed by dieckol treatments were significantly increased compared to the positive control. The level of GOT, GPT and MDA in the serum of the dieckol treated groups were reduced dose dependently than the control, significantly. The antioxidant enzymes including CAT, and GSH-px levels were increased significantly compared to the positive control. However, no significant differences were observed on hepatic histophathological analysis in dieckol treated groups dose dependently. Down-regulation of Bax and up-regulation of Bcl-xl protein expressions were observed in liver tissues of the dieckol administered groups. These results suggested that, dieckol can be developed as a therapeutic agent for liver disease by oxidative stress. (c) 2013 Elsevier B.V. All rights reserved.

引用

页码：517 / 523

页数：7

共 40 条

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Antioxidant activities of phlorotannins purified from Ecklonia cava on free radical scavenging using ESR and H2O2-mediated DNA damage [J].