Aging and neuropathic pain

被引：28

作者：

Novak, JC

Lovell, JA

Stuesse, SL

Cruce, WLR

McBurney, DL

Crisp, T

机构：

[1] NE Ohio Univ, Coll Med, Dept Neurobiol, Rootstown, OH 44272 USA

[2] Kent State Univ, Dept Biol Sci, New Philadelphia, OH 44663 USA

来源：

BRAIN RESEARCH | 1999年 / 833卷 / 02期

关键词：

hyperalgesia; nociception; nerve injury; rat; sciatic nerve ligation;

D O I：

10.1016/S0006-8993(99)01522-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Although chronic neuropathic pain disorders are more prevalent in the senescent population, little is known about how the aging process alters the thermal hyperalgesic sensitivity to peripheral nerve injury. In this study, neuropathic pain was induced in young, mature and aged FBNF1 hybrid rats via unilateral ligation of the left sciatic nerve. The extent to which the aging process affects the thermal hyperalgesic responsiveness of these animals was investigated. The results demonstrate that the aging process differentially alters nociceptive processing. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：308 / 310

页数：3

共 16 条

[1] ENDOGENOUS PAIN CONTROL-SYSTEMS - BRAIN-STEM SPINAL PATHWAYS AND ENDORPHIN CIRCUITRY [J].