Effect of electro-acupuncture on lateralization of the human swallowing motor cortex excitability in healthy subjects: study protocol for a single-blind, randomized controlled trial

被引：18

作者：

Li, Minying ^{[1
]}

Wang, Lin ^{[1
]}

Xu, Nenggui ^{[1
]}

Tang, Xiaorong ^{[1
]}

Xu, Mindong ^{[1
]}

Liu, Jianhua ^{[2
]}

Huang, Jianpeng ^{[2
]}

Schlaeger, Judith M. ^{[3
]}

机构：

[1] Guangzhou Univ Chinese Med, Med Coll Acu Moxi & Rehabil, South China Res Ctr Acupuncture & Moxibust, Guangzhou 510006, Guangdong, Peoples R China

[2] Tradit Chinese Med Hosp Guangdong Prov, Guangzhou 510000, Guangdong, Peoples R China

[3] Univ Illinois, Coll Nursing, Dept Women Children & Family Hlth Sci, 845 S Damen Ave M-C 802, Chicago, IL 60612 USA

来源：

TRIALS | 2019年 / 20卷 / 1期

基金：

中国国家自然科学基金;

关键词：

Electro-acupuncture; Lateralization of the swallowing motor cortex; Dysphagia; Stroke; Transcranial magnetic stimulation; OROPHARYNGEAL DYSPHAGIA; RISK-FACTOR; ACUPUNCTURE; ACTIVATION; REORGANIZATION; PREVALENCE; PNEUMONIA; RECOVERY; NEEDLE;

D O I：

10.1186/s13063-019-3267-x

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Background: Numerous randomized controlled trials on the effects of electro-acupuncture have been conducted to treat dysphagia as a sequela of stroke. However, the normal physiological mechanisms of swallowing and the pathological mechanisms of dysphagia are not fully understood. The purpose of this study is to investigate whether lateralization of the human swallowing motor cortex excitability in healthy subjects will be influenced by electro-acupuncture to Lianquan (CV 23) and Fengfu (GV 16), which may provide insight into the pathological mechanisms of dysphagia after stroke. Methods: We designed a single-blind, randomized, sham-controlled trial in which 40 healthy subjects will be recruited. Subjects will be randomized 1:1 into two groups: the electro-acupuncture group and the sham-control electro-acupuncture group. The swallowing motor cortex will be located in both groups using a neuroimaging navigation system. Then left and right cortical stimulation will be measured by transcranial magnetic stimulation (TMS) before and after electro-acupuncture or sham electro-acupuncture. The electro-acupuncture or sham electro-acupuncture interventions will last for 15 min. The primary outcome measure will be percent change in the resting motor threshold (RMT) of the mylohyoid. The secondary outcome measures will be the amplitude (mu V) and latency (ms) of the motor evoked potential (MEP) of the mylohyoid as a proxy for the TMS evoked potential. All outcomes will be measured at baseline and after the electro-acupuncture or sham electro-acupuncture treatment. Discussion: The aim of this trial is to explore whether lateralization of the human swallowing motor cortex excitability in healthy subjects is present, and to determine if electro-acupuncture to acupuncture points Lianquan (CV 23) and Fengfu (GV 16) will exert an effect on it under normal physiological conditions.

引用

页数：9

共 35 条

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