A study of rivastigmine liposomes for delivery into the brain through intranasal route

被引：119

作者：

Arumugam, Karthik ^{[1
]}

Subramanian, Ganesa Sundararajan ^{[1
]}

Mallayasamy, Surulivel Rajan ^{[1
]}

Averineni, Ranjith Kumar ^{[1
]}

Reddy, Meka Sreenivasa ^{[1
]}

Udupa, Nayanabhirama ^{[1
]}

机构：

[1] Manipal Coll Pharmaceut Sci, Dept Pharmaceut Qual Assurance, Manipal 576104, Karnataka, India

来源：

ACTA PHARMACEUTICA | 2008年 / 58卷 / 03期

关键词：

rivastigmine; liposomes; intranasal administration; brain drug delivery; pharmacokinetics;

D O I：

10.2478/v10007-008-0014-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The present study is mainly aimed at delivering a drug into the brain via the intranasal route using a liposomal formulation. For this purpose, rivastigmine, which is used in the management of Alzheimer's disease, was selected as a model drug. Conventional liposomes were formulated by the lipid layer hydration method using cholesterol and soya lecithin as lipid components. The concentration of rivastigmine in brain and plasma after intranasal liposomes, free drug and per oral administration was studied in rat models. A significantly higher level of drug was found in the brain with intranasal liposomes of rivastigmine compared to the intranasal free drug and the oral route. Intranasal liposomes had a longer half-life in the brain than intranasally or orally administered free drug. Delivering rivastigmine liposomes through the intranasal route for the treatment of Alzheimer's disease might be a new approach to the management of this condition.

引用

页码：287 / 297

页数：11

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