Influence of hypertension on early renal insufficiency in autosomal dominant polycystic kidney disease

被引:18
作者
Gonzalo, A [1 ]
Gallego, A [1 ]
Rivera, M [1 ]
Orte, L [1 ]
Ortuno, J [1 ]
机构
[1] UNIV COMPLUTENSE MADRID,DEPT GENET,E-28040 MADRID,SPAIN
来源
NEPHRON | 1996年 / 72卷 / 02期
关键词
hypertension; polycystic kidney disease; renal failure; progression;
D O I
10.1159/000188846
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
To determine the potential effect of hypertension on early renal function deterioration, 30 patients (13 normotensive and 17 hypertensive) with autosomal dominant polycystic kidney disease and initially normal renal function were retrospectively analyzed. The decline in renal function was estimated by the slope of the linear regression of creatinine clearance versus time. Analysis was made in terms of standardized slope (slope divided by its standard deviation, i.e., measured in standard deviation units). In the hypertensive group the mean standardized slope was significantly higher than in the normotensive group (-10.89 and -4.98, respectively; p < 0.001). The average mean arterial pressure was significantly lower in the normotensive group with respect to the hypertensive one (95 and 109 mm Hg, respectively; p < 0.0001). There was a significant negative linear relationship between the average values of systolic, diastolic, and mean arterial pressures and standardized slopes. The best prediction equation for renal function deterioration was obtained using a multiple linear regression model in which independent variables were maximum and average diastolic pressures. Therefore, prior to renal insufficiency, a high arterial pressure had a significant contribution to renal function deterioration.
引用
收藏
页码:225 / 230
页数:6
相关论文
共 26 条
[1]   AGE AT CLINICAL ONSET AND AT ULTRASONOGRAPHIC DETECTION OF ADULT POLYCYSTIC KIDNEY-DISEASE - DATA FOR GENETIC-COUNSELING [J].
BEAR, JC ;
MCMANAMON, P ;
MORGAN, J ;
PAYNE, RH ;
LEWIS, H ;
GAULT, MH ;
CHURCHILL, DN .
AMERICAN JOURNAL OF MEDICAL GENETICS, 1984, 18 (01) :45-53
[2]   PROGRESSION OF RENAL-INSUFFICIENCY - ROLE OF BLOOD-PRESSURE [J].
BRAZY, PC ;
STEAD, WW ;
FITZWILLIAM, JF .
KIDNEY INTERNATIONAL, 1989, 35 (02) :670-674
[3]   THE RENIN-ANGIOTENSIN ALDOSTERONE SYSTEM AND AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY-DISEASE [J].
CHAPMAN, AB ;
JOHNSON, A ;
GABOW, PA ;
SCHRIER, RW .
NEW ENGLAND JOURNAL OF MEDICINE, 1990, 323 (16) :1091-1096
[4]   PREDICTION OF CREATININE CLEARANCE FROM SERUM CREATININE [J].
COCKCROFT, DW ;
GAULT, MH .
NEPHRON, 1976, 16 (01) :31-41
[5]   RENAL STRUCTURE AND HYPERTENSION IN AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY-DISEASE [J].
GABOW, PA ;
CHAPMAN, AB ;
JOHNSON, AM ;
TANGEL, DJ ;
DULEY, IT ;
KAEHNY, WD ;
MANCOJOHNSON, M ;
SCHRIER, RW .
KIDNEY INTERNATIONAL, 1990, 38 (06) :1177-1180
[6]   FACTORS AFFECTING THE PROGRESSION OF RENAL-DISEASE IN AUTOSOMAL-DOMINANT POLYCYSTIC KIDNEY-DISEASE [J].
GABOW, PA ;
JOHNSON, AM ;
KAEHNY, WD ;
KIMBERLING, WJ ;
LEZOTTE, DC ;
DULEY, IT ;
JONES, RH .
KIDNEY INTERNATIONAL, 1992, 41 (05) :1311-1319
[7]   PREDICTING GLOMERULAR FUNCTION FROM ADJUSTED SERUM CREATININE [J].
GAULT, MH ;
LONGERICH, LL ;
HARNETT, JD ;
WESOLOWSKI, C .
NEPHRON, 1992, 62 (03) :249-256
[8]   SHAPE OF THE RELATIONSHIP BETWEEN HYPERTENSION AND THE RATE OF PROGRESSION OF RENAL-FAILURE IN AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY-DISEASE [J].
GONZALO, A ;
GALLEGO, A ;
RIVERA, M ;
ORTE, L ;
ORTUNO, J .
NEPHRON, 1992, 62 (01) :52-57
[9]   CLINICAL-FEATURES AND PROGNOSIS OF ADULT POLYCYSTIC KIDNEY-DISEASE [J].
GONZALO, A ;
RIVERA, M ;
QUEREDA, C ;
ORTUNO, J .
AMERICAN JOURNAL OF NEPHROLOGY, 1990, 10 (06) :470-474
[10]   CYST FORMATION AND GROWTH IN AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY-DISEASE [J].
GRANTHAM, JJ ;
GEISER, JL ;
EVAN, AP .
KIDNEY INTERNATIONAL, 1987, 31 (05) :1145-1152