Distribution of the mRNA for protein phosphatase T in rat brain

被引：13

作者：

Becker, W

Buttini, M

Limonta, S

Boddeke, H

Joost, HG

机构：

[1] RHEIN WESTFAL TH AACHEN,INST PHARMAKOL & TOXIKOL,D-52057 AACHEN,GERMANY

[2] SANDOZ PHARMA LTD,PRECLIN RES 360 605,CH-4002 BASEL,SWITZERLAND

来源：

MOLECULAR BRAIN RESEARCH | 1996年 / 36卷 / 01期

关键词：

in situ hybridization; mRNA; protein phosphatase T; PP5; rat brain;

D O I：

10.1016/0169-328X(95)00233-I

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We have recently cloned a novel protein serine/threonine phosphatase (PPT) from rat mRNA which is predominantly expressed in the brain (Becker et al., J. Biol. Chem., 269 (1994) 22586-22592). In the present study, the regional distribution of PPT mRNA in the brain of adult rats was characterized by in situ hybridization histochemistry. PPT mRNA was found to be differentially expressed throughout the rat brain. Highest transcript levels were found in specific neuronal populations (hippocampus, piriform cortex, taenia tecta, medial habenula, granular cell layer of the cerebellum) as well as in the choroid plexus of the third and lateral ventricles. In contrast, expression levels in some brain areas, e.g., caudate putamen and white matter, were beyond the detection limit of in situ hybridization. The pattern of expression of PPT in rat brain differs from that of other protein serine/threonine phosphatases and may reflect specific functions of this phosphatase.

引用

页码：23 / 28

页数：6

共 18 条

[1] LOCALIZATION OF MESSENGER-RNA FOR PROTEIN PHOSPHATASE 2A IN THE BRAIN OF ADULT-RATS [J].