Polymorphisms Cyclooxygenase-2-765G>C and Interleukin-6-174G>C Are Associated with Serum Inflammation Markers in a High Cardiovascular Risk Population and Do Not Modify the Response to a Mediterranean Diet Supplemented with Virgin Olive Oil or Nuts

被引：40

作者：

Corella, Dolores ^{[1
,2
]}

Gonzalez, Jose Ignacio ^{[1
,2
]}

Bullo, Monica

Carrasco, Paula ^{[1
]}

Portoles, Olga ^{[1
]}

Diez-Espino, Javier ^{[3
]}

Covas, Maria Isabel ^{[2
,4
]}

Ruiz-Gutierrez, Valentina ^{[5
]}

Gomez-Gracia, Enrique ^{[6
]}

Aros, Fernando ^{[7
]}

Fiol, Miquel ^{[2
,8
]}

Herrera, Manuel Conde ^{[9
]}

Santos, Jose Manuel ^{[2
,10
]}

Saez, Guillermo ^{[11
]}

Lamuela, Rosa ^{[12
]}

Lahoz, Carlos ^{[13
]}

Vinyoles, Ernest ^{[14
]}

Ros, Emilio ^{[2
,15
]}

Estruch, Ramon ^{[2
,16
]}

机构：

[1] Univ Valencia, Sch Med, Dept Prevent Med & Publ Hlth, Valencia 46010, Spain

[2] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr, Madrid 28029, Spain

[3] Univ Rovira & Virgili, Sch Med, Dept Prevent Med & Publ Hlth, E-43201 Reus, Spain

[4] Municipal Inst Med Res, Cardiovasc Epidemiol Unit, Barcelona 08003, Spain

[5] CSIC, Inst Grasa, Seville 41012, Spain

[6] Univ Malaga, Sch Med, Dept Epidemiol, E-29071 Malaga, Spain

[7] Hosp Txagorritxu, Dept Cardiol, Vitoria 01009, Spain

[8] Hosp Son Dureta, Univ Inst Hlth Sci Invest, Palma de Mallorca 07014, Spain

[9] Hosp Univ Virgen Rocio, Dept Epidemiol & Publ Hlth, Seville 41013, Spain

[10] Primary Care Div Sevilla, San Pablo Hlth Ctr, Dept Family Med, Seville 41007, Spain

[11] Univ Valencia, Dept Biochem & Mol Biol, Valencia 46010, Spain

[12] Sch Pharm, Dept Nutr & Bromatol, Barcelona 08007, Spain

[13] Hosp Carlos III, Arteriosclerosis Unit, Madrid 28029, Spain

[14] Primary Hlth Care Div, Barcelona 08036, Spain

[15] Inst Invest Biomed August Pi Sunyer, Endocrinol & Nutr Serv, Lipid Clin, Barcelona 08036, Spain

[16] Inst Invest Biomed August Pi Sunyer, Hosp Clin, Dept Internal Med, Barcelona 08036, Spain

来源：

JOURNAL OF NUTRITION | 2009年 / 139卷 / 01期

关键词：

CORONARY-HEART-DISEASE; G/C PROMOTER POLYMORPHISM; SOLUBLE VASCULAR CELL; C-REACTIVE PROTEIN; INTERLEUKIN-6; GENE; MYOCARDIAL-INFARCTION; NO ASSOCIATION; ADHESION MOLECULE-1; ARTERY-DISEASE; ATHEROSCLEROSIS;

D O I：

10.3945/jn.108.093054

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Inflammation is involved in cardiovascular diseases. Some studies have found that the Mediterranean diet (MD) can reduce serum concentrations of inflammation markers. However, none of these studies have analyzed the influence of genetic variability in such a response. Our objective was to study the effect of the -765G>C polymorphism in the cyclooxygenase-2 (COX-2) gene and the -174G>C polymorphism in the interleukin-6 (IL-6) gene on serum concentrations of IL-6, C-reactive protein, intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule-1 as well as their influence on the response to a nutritional intervention with MD. An intervention study in a high cardiovascular risk Mediterranean population (314 men and 407 women) was undertaken. Participants were randomly assigned to consume a low-fat control diet or a MD supplemented with virgin olive oil or nuts. Measures were obtained at baseline and after a 3-mo intervention period. At baseline, the COX-2 -765G>C polymorphism was associated with lower serum IL-6 (5.85 +/- 4.82 in GG vs. 4.74 +/- 4.14 ng/L in C-allele carriers; P = 0.002) and ICAM-1 (265.8 +/- 114.8 in GG vs. 243.0 +/- 107.1 mu g/L in C-carriers; P = 0.018) concentrations. These differences remained significant after multivariate adjustment. The IL-6-174G>C polymorphism was associated with higher (CC vs. G-carriers) serum ICAM-1 concentrations in both men and women and with higher serum IL-6 concentrations in men. Following the dietary intervention, no significant gene x diet interactions were found. In conclusion, although COX-2 -765G>C and IL-6 -174G>C polymorphisms were associated with inflammation, consuming a MD (either supplemented with virgin olive oil or nuts) reduced the concentration of inflammation markers regardless of these polymorphisms. J. Nutr. 139: 128-134, 2009.

引用

页码：128 / 134

页数：7

共 39 条

[1] Interleukin-6 -174G>C polymorphism and risk of coronary heart disease in West of Scotland Coronary Prevention Study (WOSCOPS) [J].