Impaired phosphorylation of cyclic AMP response element binding protein in the hippocampus of dementia of the Alzheimer type

被引：182

作者：

Yamamoto-Sasaki, M

Ozawa, H

Saito, T

Rösler, M

Riederer, P

机构：

[1] Univ Wurzburg, Dept Psychiat, D-97080 Wurzburg, Germany

[2] Sapporo Med Univ, Sch Med, Dept Neuropsychiat, Chuo Ku, Sapporo, Hokkaido 0608543, Japan

来源：

BRAIN RESEARCH | 1999年 / 824卷 / 02期

关键词：

cyclic AMP response element binding protein; dementia of the Alzheimer type; postmortem human brain; immunoblotting; cyclic AMP signal transduction system;

D O I：

10.1016/S0006-8993(99)01220-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Cyclic AMP (cAMP) is disrupted in the brain in dementia of the Alzheimer type (DAT). We investigated whether the cAMP reduction is accompanied by an alteration in the cAMP response element binding protein (CREB) downstream in DAT and control hippocampi. Immunoreactivity of pCREB was significantly decreased in DAT, while total CREB level was unchanged. These findings indicate that impaired cAMP signaling may contribute to the pathophysiology of the disease. (C) 1999 Elsevier Science B.V. All rights reserved.

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收藏

页码：300 / 303

页数：4

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