Genetic analysis of ossification of the posterior longitudinal ligament

被引：109

作者：

Matsunaga, S ^{[1
]}

Yamaguchi, M ^{[1
]}

Hayashi, K ^{[1
]}

Sakou, T ^{[1
]}

机构：

[1] Kagoshima Univ, Fac Med, Dept Orthopaed Surg, Kagoshima 8908520, Japan

来源：

SPINE | 1999年 / 24卷 / 10期

关键词：

Family study; Human leukocyte antigen haplotype analysis; Ossification of the posterior longitudinal ligament;

D O I：

10.1097/00007632-199905150-00002

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Study Design. The human leukocyte antigen (HLA) haplotypes in families of patients with known ossification of the posterior longitudinal ligament (OPLL) were reviewed. Objective. To clarify how genetic factors relate to the development of OPLL. Summary of Background Data. The association between genetic factors and the development of OPLL is still unknown. Materials and Methods. The association between HLA haplotypes and OPLL was studied in families of 24 patients with OPLL. Results. The prevalence of OPLL was higher in the siblings showing a higher share of identical HLA haplotypes: 10 (53%) of 19 with concurrence of two strands, and 5 (24%) of 21 with concurrence of one strand. Of 21 subjects who had no HLA haplotype identical with that in OPLL patients, only one showed evidence of OPLL. Conclusion. Genetic factors predispose toward the development of OPLL.

引用

页码：937 / 937

页数：1

共 8 条

[1]

Epstein N.E., The surgical management of ossification of the posterior longitudinal ligament in 43 North Americans, Spine, 19, pp. 664-672, (1994)

[2]

Matsunaga S., Sakou T., Taketomi E., Yamaguchi M., Okano T., The natural course of myelopathy caused by ossification of the posterior longitudinal ligament in the cervical spine, Clin Orthop, 305, pp. 168-177, (1994)

[3]

McAfee P.C., Regan J.J., Bohlman H.H., Cervical cord compression from ossification of the posterior longitudinal ligament in non-orientals, J Bone Joint Surg [Br], 69, pp. 569-573, (1987)

[4]

Miura Y., Furusho T., Ibaraki K., Takemitu Y., Analysis of Twins. 1991 Report on the Ossification of the Spinal Ligaments, pp. 5-7, (1992)

[5]

Sakou T., Taketomi E., Matsunaga S., Et al., Genetic study of ossification of the posterior longitudinal ligament in the cervical spine with human leukocyte anti-gen haplotype, Spine, 6, pp. 1249-1252, (1991)

[6]

Terasaki P.I., Bernoco D., Park M.S., Ozturk G., Iwaki Y., Microdroplet testing for HLA-A,B,C antigens, Am J Clin Pathol, 69, pp. 103-120, (1978)

[7]

Terayama K., Genetic studies on ossification of the posterior longitudinal ligament of the spine, Spine, 14, pp. 1184-1191, (1989)

[8]

Yone K., Sakou T., Yanase M., Ijiri K., Preoperative and postoperative magnetic resonance imaging evaluations of the spinal cord in cervical myelopathy, Spine, 17, (1992)

← 1 →