A novel approach to observing synergy effects of PHSRN on integrin-RGD binding using intelligent surfaces

被引：58

作者：

Ebara, Mitsuhiro ^{[2
]}

Yamato, Masayuki ^{[1
]}

Aoyagi, Takao ^{[1
]}

Kikuchi, Akihiko ^{[1
]}

Sakai, Kiyotaka ^{[2
]}

Okano, Teruo ^{[1
]}

机构：

[1] Tokyo Womens Med Univ, Inst Advanced Biomed Engn & Sci, Shinjuku Ku, Tokyo 1628666, Japan

[2] Waseda Univ, Dept Appl Chem, Tokyo 1698555, Japan

来源：

ADVANCED MATERIALS | 2008年 / 20卷 / 16期

关键词：

D O I：

10.1002/adma.200702308

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel assay for measuring time-dependant ligand-receptor affinity changes is developed based on a peptide-immobilized temperature-responsive surface, as schematically illustrated in the figure. The grafted thermoresponsive polymer acts as an "on-off" switch for mediating integrin-peptide bonding. At temperatures above and below the lower critical solution temperature (LCST), the peptides are accessible and shielded from integrin access, respectively.

引用

页码：3034 / 3038

页数：5

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[2]

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[4]

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