Wavelength dependent photodynamic effects on chemically induced rat bladder tumors following intravesical instillation of 5-aminolevulinic acid

被引：16

作者：

Stocker, S ^{[1
]}

Knuchel, R ^{[1
]}

Sroka, R ^{[1
]}

Kriegmair, M ^{[1
]}

Steinbach, P ^{[1
]}

Baumgartner, R ^{[1
]}

机构：

[1] UNIV REGENSBURG,INST PATHOL,D-8400 REGENSBURG,GERMANY

来源：

JOURNAL OF UROLOGY | 1997年 / 157卷 / 01期

关键词：

bladder cancer; 5-aminolevulinic acid; protoporphyrin IX; photodynamic therapy;

D O I：

10.1016/S0022-5347(01)65377-1

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose: The aim of the study was to determine photodynamic effects in chemically induced rat bladder tumors after intravesical instillations of 5-aminolevulinic acid (5-ALA) and PDT-dependence on laser wavelength and Light dose. Material and Methods: Following intravesical instillation of a 5-ALA solution (40 mg 5-ALA in isotonic saline and sodium-bicarbonate) rat bladder tumors have been treated with integral irradiation using laser light at wavelengths of lambda = 630 nm and lambda = 635 nn in a light dose range of 15 to 100 J/cm(2). Results: A significantly higher amount of necrosis including damage of normal urothelium was obtained in rat bladder tumors using laser Light at lambda = 635 nm. Conclusions: For 5-ALA assisted photodynamic treatment of superficial bladder cancer in patients the irradiation wavelength of lambda = 635 nm is recommended.

引用

页码：357 / 361

页数：5

共 17 条

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[2]

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