Quassinoids as inhibitors of Epstein-Barr virus early antigen activation

被引：17

作者：

Kubota, K

Fukamiya, N

Tokuda, H

Nishino, H

Tagahara, K

Lee, KH

Okano, M

机构：

[1] HIROSHIMA UNIV,FAC INTEGRATED ARTS & INTEGRATED ARTS & SCI,HIGASHIHIROSHIMA 739,JAPAN

[2] KYOTO PREFECTURAL UNIV MED,DEPT BIOCHEM,KYOTO,JAPAN

[3] KOBE PHARMACEUT UNIV,FAC PHARMACEUT SCI,KOBE,HYOGO 658,JAPAN

[4] UNIV N CAROLINA,SCH PHARM,NAT PROD LAB,CHAPEL HILL,NC 27599

来源：

CANCER LETTERS | 1997年 / 113卷 / 1-2期

关键词：

antitumor promoting effect; Epstein-Barr virus activation test; quassinoids; structure-activity relationships;

D O I：

10.1016/S0304-3835(97)04607-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Short-term in vitro assays for tumor promoters and antitumor promoters (Epstein-Barr virus activation test) were carried out for 14 quassinoids isolated from Ailanthus altissima. Some quassinoids, including ailantinol B, ailantinol C, ailanthone, and shinjulactone A, showed moderate activity at a molar ratio of 1:100 (TPA/quassinoids), and the results led to the elucidation of structure-activity relationships. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：165 / 168

页数：4

共 9 条

[1]

STUDIES ON INHIBITORS OF SKIN-TUMOR PROMOTION - INHIBITORY EFFECTS OF TRITERPENES FROM COCHLOSPERMUM-TINCTORIUM ON EPSTEIN-BARR VIRUS-ACTIVATION [J].