Metformin Is Associated with Higher Incidence of Acidosis, but Not Mortality, in Individuals with COVID-19 and Pre-existing Type 2 Diabetes

被引：127

作者：

Cheng, Xu ^{[1
,2
]}

Liu, Ye-O ^{[2
,3
]}

Li, Haomiao ^{[2
,3
]}

Zhang, Xin ^{[2
]}

Lei, Fang ^{[1
,2
]}

Qin, Juan-Juan ^{[2
,3
]}

Chen, Ze ^{[2
,3
]}

Deng, Ke-Qiong ^{[1
]}

Lin, Lijin ^{[2
,3
]}

Chen, Ming-Ming ^{[2
,3
]}

Song, Xiaohui ^{[2
,3
]}

Xia, Meng ^{[2
]}

Huang, Xuewei ^{[2
,3
]}

Liu, Weifang ^{[1
,2
]}

Cai, Jingjing ^{[4
]}

Zhang, Xiao-Jing ^{[2
,3
]}

Zhou, Feng ^{[2
,5
]}

Zhang, Peng ^{[2
,5
]}

Wang, Yibin ^{[6
,7
,8
]}

Ma, Xinliang ^{[9
]}

Xu, Qingbo ^{[10
]}

Yang, Juan ^{[2
,3
]}

Ye, Ping ^{[11
]}

Mao, Weiming ^{[12
]}

Huang, Xiaodong ^{[13
,14
]}

Xia, Jiahong ^{[15
]}

Zhang, Bing-Hong ^{[16
]}

Guo, Jiao ^{[17
,18
,19
]}

Zhu, Lihua ^{[2
,3
]}

Lu, Zhibing ^{[1
]}

Yuan, Yufeng ^{[20
]}

Wei, Xiang ^{[21
]}

She, Zhi-Gang ^{[2
,3
]}

Ji, Yan-Xiao ^{[2
,5
]}

Li, Hongliang ^{[1
,2
,3
,5
]}

机构：

[1] Wuhan Univ, Zhongnan Hosp, Sch Basic Med Sci, Dept Cardiol, Wuhan, Peoples R China

[2] Wuhan Univ, Inst Model Anim, Wuhan, Peoples R China

[3] Wuhan Univ, Dept Cardiol, Renmin Hosp, Wuhan, Peoples R China

[4] Cent South Univ, Xiangya Hosp 3, Dept Cardiol, Changsha 410000, Peoples R China

[5] Wuhan Univ, Med Sci Res Ctr, Zhongnan Hosp, Wuhan, Peoples R China

[6] Univ Calif Los Angeles, David Geffen Sch Med, Dept Anesthesiol, Cardiovasc Res Labs, Los Angeles, CA 90095 USA

[7] Univ Calif Los Angeles, David Geffen Sch Med, Dept Physiol, Cardiovasc Res Labs, Los Angeles, CA 90095 USA

[8] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Cardiovasc Res Labs, Los Angeles, CA 90095 USA

[9] Thomas Jefferson Univ, Dept Emergency Med, Philadelphia, PA 19004 USA

[10] Queen Mary Univ London, Ctr Clin Pharmacol, William Harvey Res Inst, London, England

[11] Huazhong Univ Sci & Technol, Cent Hosp Wuhan, Tongji Med Coll, Dept Cardiol, Wuhan, Peoples R China

[12] Huanggang Cent Hosp, Dept Gen Surg, Huanggang, Peoples R China

[13] Wuhan Univ, Dept Gastroenterol, Wuhan Hosp 3, Wuhan, Peoples R China

[14] Wuhan Univ, Tongren Hosp, Wuhan, Peoples R China

[15] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Cardiovasc Surg, Wuhan, Peoples R China

[16] Wuhan Univ, Dept Neonatol, Renmin Hosp, Wuhan, Peoples R China

[17] Guangdong Pharmaceut Univ, Guangdong Metab Dis Res Ctr Integrated Chinese &, Guangdong TCM Key Lab Metab Dis, Guangzhou 510006, Peoples R China

[18] Guangdong Pharmaceut Univ, Key Lab Glucolipid Metab Disorder, Minist Educ China, Guangdong TCM Key Lab Metab Dis, Guangzhou 510006, Peoples R China

[19] Guangdong Pharmaceut Univ, Inst Chinese Med, Guangdong TCM Key Lab Metab Dis, Guangzhou 510006, Peoples R China

[20] Wuhan Univ, Dept Hepatobiliary & Pancreat Surg, Zhongnan Hosp, Wuhan, Peoples R China

[21] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Div Cardiothorac & Vasc Surg, Wuhan, Peoples R China

来源：

CELL METABOLISM | 2020年 / 32卷 / 04期

基金：

国家重点研发计划; 美国国家科学基金会; 中国国家自然科学基金;

关键词：

LACTIC-ACIDOSIS; MECHANISMS; DIAGNOSIS; PROTECTS; OUTCOMES; LACTATE; SEPSIS; DRUG;

D O I：

10.1016/j.cmet.2020.08.013

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

The safety and efficacy of anti-diabetic drugs are critical for maximizing the beneficial impacts of well-controlled blood glucose on the prognosis of individuals with COVID-19 and pre-existing type 2 diabetes (T2D). Metformin is the most commonly prescribed first-line medication for T2D, but its impact on the outcomes of individuals with COVID-19 and T2D remains to be clarified. Our current retrospective study in a cohort of 1,213 hospitalized individuals with COVID-19 and pre-existing T2D indicated that metformin use was significantly associated with a higher incidence of acidosis, particularly in cases with severe COVID-19, but not with 28-day COVID-19-related mortality. Furthermore, metformin use was significantly associated with reduced heart failure and inflammation. Our findings provide clinical evidence in support of continuing metformin treatment in individuals with COVID-19 and pre-existing T2D, but acidosis and kidney function should be carefully monitored in individuals with severe COVID-19.

引用

页码：537 / +

页数：14

共 51 条

[1]

American Diabetes Association, 2019, CARE, V42, pS90

[2]

The journey of metformin from glycaemic control to mTOR inhibition and the suppression of tumour growth [J].