Quinazolinecarboline alkaloid evodiamine as scaffold for targeting topoisomerase I and sirtuins

被引：43

作者：

Christodoulou, Michael S. ^{[1
]}

Sacchetti, Alessandro ^{[2
]}

Ronchetti, Valentina ^{[1
]}

Caufin, Stefania ^{[1
]}

Silvani, Alessandra ^{[1
]}

Lesma, Giordano ^{[1
]}

Fontana, Gabriele ^{[3
]}

Minicone, Fabrizio ^{[1
]}

Riva, Benedetta ^{[1
]}

Ventura, Micol ^{[1
]}

Lahtela-Kakkonen, Maija ^{[4
]}

Jarho, Elina ^{[4
]}

Zuco, Valentina ^{[5
]}

Zunino, Franco ^{[5
]}

Martinet, Nadine ^{[6
]}

Dapiaggi, Federico ^{[1
]}

Pieraccini, Stefano ^{[1
,7
]}

Sironi, Maurizio ^{[1
,7
]}

Dalla Via, Lisa ^{[8
]}

Gia, Ornella Maria ^{[8
]}

Passarella, Daniele ^{[1
]}

机构：

[1] Univ Milan, Dipartimento Chim, I-20133 Milan, Italy

[2] Politecn Milan, Dipartimento Chim Mat & Ingn Chim Giulio Natta, I-20131 Milan, Italy

[3] Indena Spa, Milan, Italy

[4] Univ Eastern Finland, Sch Pharm, Kuopio 70211, Finland

[5] Fdn IRCCS Ist Nazl Studio & Cura Tumori, I-20133 Milan, Italy

[6] CNRS, Inst Chem, UMR 7272, F-06108 Nice 2, France

[7] INSTM Unita Ric Milano, Consorzio Interuniv Nazl Sci & Tecnol Mat, I-20133 Milan, Italy

[8] Univ Padua, Dipartimento Sci Farmaco, I-35131 Padua, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2013年 / 21卷 / 22期

基金：

芬兰科学院;

关键词：

Quinazolinecarboline alkaloids; Evodiamine; Sirtuins; Topoisomerase I; INHIBITORS; APOPTOSIS; SIRT2; DISCOVERY; IDENTIFICATION; DERIVATIVES; POTENT; CELLS; ACID; CONSTITUENT;

D O I：

10.1016/j.bmc.2013.09.030

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

This paper reports the synthesis of a series of evodiamine derivatives. We assayed the ability to inhibit cell growth on three human tumour cell lines (H460, MCF-7 and HepG2) and we evaluated the capacity to interfere with the catalytic activity of topoisomerase I both by the relaxation assay and the occurrence of the cleavable complex. Moreover, whose effect on sirtuins 1, 2 and 3 was investigated. Finally, molecular docking analyses were performed in an attempt to rationalize the biological results. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：6920 / 6928

页数：9

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