DNA Targets of AID: Evolutionary Link Between Antibody Somatic Hypermutation and Class Switch Recombination

被引：50

作者：

Hackney, Jason A. ^{[1
]}

Misaghi, Shahram ^{[1
]}

Senger, Kate ^{[1
]}

Garris, Christopher ^{[1
]}

Sun, Yonglian ^{[1
]}

Lorenzo, Maria N. ^{[1
]}

Zarrin, Ali A. ^{[1
]}

机构：

[1] Genentech Inc, Immunol Discovery Grp, San Francisco, CA 94080 USA

来源：

ADVANCES IN IMMUNOLOGY, VOL 101 | 2009年 / 101卷

关键词：

INDUCED CYTIDINE DEAMINASE; SINGLE-STRANDED-DNA; SYSTEMIC-LUPUS-ERYTHEMATOSUS; ACTIVATION-INDUCED DEAMINASE; CONSTANT-REGION LOCUS; HEAVY-CHAIN LOCUS; B-CELLS; S-MU; IMMUNOGLOBULIN GENES; GENOMIC INSTABILITY;

D O I：

10.1016/S0065-2776(08)01005-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

As part of the adaptive immune response, B cells alter their functional immunoglobulin (Ig) receptor genes through somatic hypermutation (SHM) and/or class switch recombination (CSR) via processes that are initiated by activation induced cytidine deaminase (AID). These genetic modifications are targeted at specific sequences known as Variable (V) and Switch (5) regions. Here, we analyze and review the properties and function of AID target sequences across species and compare them with non-Ig sequences, including known translocation hotspots. We describe properties of the S sequences, and discuss species and isotypic differences among S regions. Common properties of SHM and CSR target sequences suggest that evolution of S regions might involve the duplication and selection of SHM hotspots.

引用

页码：163 / 189

页数：27

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