Butea monosperma and chemomodulation:: Protective role against thioacetamide-mediated hepatic alterations in Wistar rats

被引：23

作者：

Sehrawat, A ^{[1
]}

Khan, TH ^{[1
]}

Prasad, L ^{[1
]}

Sultana, S ^{[1
]}

机构：

[1] Jamia Hamdard Hamdard Univ, Fac Sci, Sect Chemoprevent & Nutr Toxicol, Dept Med Elementol & Toxicol, New Delhi 110062, India

来源：

PHYTOMEDICINE | 2006年 / 13卷 / 03期

关键词：

Butea monosperma; TAA; oxidative stress; promotion;

D O I：

10.1016/j.phymed.2004.11.007

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The present study was carried out to study the effect of Butea monosperma, a known liver acting drug on the tumor promotion related events of carcinogenesis in rat liver. Thioacetamide (TAA) was used to induce tumor promotion response and oxidative stress and caused significant depletion in the detoxification and antioxidant enzyme armory with concomitant elevation in malondialdehyde (MDA) formation, hydrogen peroxide (H2O2) generation, ornithine decarboxylase (ODC) activity and unscheduled DNA synthesis. However, B. monosperma pretreatment at two different doses restored the levels of the above-said parameters (p < 0.001) in a dose-dependent manner. The alcoholic extract of B. monosperma used in the present study seems to offer dose-dependent protection and maintain the structural integrity of hepatic cells. This was evident from the significant reduction in TAA-induced serum GOT, GPT, Lactate dehydrogenase (LDH) and gamma-Glutamyl transpeptidase activity (GGT) activities (p < 0.001). These investigations validate the use of B. monosperma in liver disorders by Ayurvedic physicians. Overall results indicate that the methanolic extract of B. monosperma possesses hepatoprotective effects and also it might suppress the promotion stage via inhibition of oxidative stress and polyamine biosynthetic pathway. (c) 2005 Elsevier GmbH. All rights reserved.

引用

页码：157 / 163

页数：7

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