Significant association of SRC protein expression with the progression, recurrence, and prognosis of oral squamous cell carcinoma in Taiwan

被引：14

作者：

Cheng, Shih-Jung ^{[1
,2
,3
]}

Kok, Sang-Heng ^{[2
,3
,4
]}

Lee, Jang-Jaer ^{[2
,3
]}

Kuo, Mark Yen-Ping ^{[1
,2
,3
]}

Cheng, Shih-Lung ^{[5
]}

Huang, Ying-Luo ^{[1
,3
]}

Chen, Hsin-Ming ^{[2
,3
,4
]}

Chang, Hao-Hueng ^{[2
,3
]}

Chiang, Chun-Pin ^{[1
,2
,3
,4
]}

机构：

[1] Natl Taiwan Univ, Sch Dent, Grad Inst Clin Dent, Taipei 10764, Taiwan

[2] Natl Taiwan Univ, Sch Dent, Dept Dent, Taipei 10764, Taiwan

[3] Natl Taiwan Univ Hosp, Coll Med, Dept Dent, Taipei, Taiwan

[4] Natl Taiwan Univ, Sch Dent, Grad Inst Oral Biol, Taipei 10764, Taiwan

[5] Far Eastern Mem Hosp, Dept Internal Med, Taipei, Taiwan

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2012年 / 34卷 / 09期

关键词：

Src protein; oral cancer; cancer progression; recurrence; prognosis; TYROSINE KINASE-ACTIVITY; NECROSIS-FACTOR-ALPHA; C-SRC; FAMILY KINASES; HEPATOCELLULAR-CARCINOMA; CANCER; OVEREXPRESSION; INHIBITION; ACTIVATION; LUNG;

D O I：

10.1002/hed.21923

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 [耳鼻咽喉科学];

摘要：

Background Src protein overexpression correlates with progression and prognosis of a variety of human cancers. Methods This study used immunohistochemistry to examine the expression of Src protein in 93 specimens of oral squamous cell carcinoma (OSCC). Results We found a significant association of high expression of Src protein (labeling indices >50%) with larger tumor size (p = .017), positive lymph node metastasis (p = .030), more advanced clinical stages (p = .007), and recurrence (p < .001) of OSCC. High expression of Src protein was identified as an independent unfavorable prognosis factor by multivariate Cox regression analysis. The KaplanMeier curve showed that patients with OSCC with high expression of Src protein had a significantly poorer cumulative survival than those with low expression of Src protein (log-rank test, p = .00267). Conclusion The expression of Src protein is significantly associated with the progression, recurrence, and prognosis of OSCCs in Taiwan. (C) 2011 Wiley Periodicals, Inc. Head Neck, 2012

引用

页码：1340 / 1345

页数：6

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