4,10-dihydro-5H-thieno[3,2-c][1]benzazepine derivatives and 9,10-dihydro-4H-thieno[2,3-c][1]benzazepine derivatives as orally active arginine vasopressin receptor antagonists

被引：13

作者：

Aranapakam, V ^{[1
]}

Albright, JD ^{[1
]}

Grosu, GT ^{[1
]}

Chan, PS ^{[1
]}

Coupet, J ^{[1
]}

Saunders, T ^{[1
]}

Ru, X ^{[1
]}

Mazandarani, H ^{[1
]}

机构：

[1] Wyeth Ayerst Res, Pearl River, NY 10965 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 13期

关键词：

D O I：

10.1016/S0960-894X(99)00278-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Synthesis and structure-activity relationships (SAR) of arginine vasopressin receptor (AVP) antagonists are described. Potent and orally active compounds are prepared when tricyclic 10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine moiety in VPA-985 1 is replaced with a compound 7 or 12. (C) 1999 Elsevier Science Ltd. All rights reserved.

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页码：1733 / 1736

页数：4

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