A systematic review of the activity of the hypothalamic-pituitary-adrenal axis in first episode psychosis

被引：128

作者：

Borges, Susana ^{[1
]}

Gayer-Anderson, Charlotte ^{[1
]}

Mondelli, Valeria ^{[1
]}

机构：

[1] Kings Coll London, Inst Psychiat, Dept Psychol Med, London SE5 9NU, England

来源：

PSYCHONEUROENDOCRINOLOGY | 2013年 / 38卷 / 05期

基金：

英国惠康基金;

关键词：

HPA axis; Cortisol; Pituitary; Glucocorticoid; Psychosis; First episode psychosis; Schizophrenia; DEXAMETHASONE-SUPPRESSION TEST; DRUG-NAIVE PATIENTS; POSTTRAUMATIC-STRESS-DISORDER; CORTISOL AWAKENING RESPONSE; MINOR PHYSICAL ANOMALIES; CHRONIC-FATIGUE-SYNDROME; ACUTE METABOLIC STRESS; 1ST-EPISODE SCHIZOPHRENIA; SALIVARY CORTISOL; ATYPICAL ANTIPSYCHOTICS;

D O I：

10.1016/j.psyneuen.2012.12.025

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Up to now studies on hypothalamic pituitary adrenal (HPA) axis activity in psychosis have shown inconsistent findings. These inconsistencies have been often ascribed to confounding effects of long duration of illness and chronic treatment with psychotropic medications of the subjects studied (chronic psychosis). In the last years, several studies have focused on the study of subjects at their first episode of psychosis to overcome these possible confounders. The aim of this paper was to review the literature investigating HPA axis activity in first episode psychosis. Findings from these studies support the presence of HPA axis hyperactivity and a blunted HPA axis response to stress at the onset of psychosis. Possible biological pathways linking these HPA axis abnormalities to the development of psychosis are discussed. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：603 / 611

页数：9

共 72 条

[1]

Abnormal cortisol awakening response predicts worse cognitive function in patients with first-episode psychosis [J].

Aas, M. ;

Dazzan, P. ;

Mondelli, V. ;

Toulopoulou, T. ;

Reichenberg, A. ;

Di Forti, M. ;

Fisher, H. L. ;

Handley, R. ;

Hepgul, N. ;

Marques, T. ;

Miorelli, A. ;

Taylor, H. ;

Russo, M. ;

Wiffen, B. ;

Papadopoulos, A. ;

Aitchison, K. J. ;

Morgan, C. ;

Murray, R. M. ;

Pariante, C. M. .

PSYCHOLOGICAL MEDICINE, 2011, 41 (03) :463-476

[2]

Enhancement of the prolactin response to d-fenfluramine in drug-naive schizophrenic patients [J].

Abel, KM ;

OKeane, V ;

Murray, RM .

BRITISH JOURNAL OF PSYCHIATRY, 1996, 168 (01) :57-60

[3]

Stress abnormalities in individuals at risk for psychosis: A review of studies in subjects with familial risk or with "at risk" mental state [J].

Aiello, Giuliano ;

Horowitz, Mark ;

Hepgul, Nilay ;

Pariante, Carmine M. ;

Mondelli, Valeria .

PSYCHONEUROENDOCRINOLOGY, 2012, 37 (10) :1600-1613

[4]

INVIVO ASSESSMENT OF PITUITARY VOLUME WITH MAGNETIC-RESONANCE-IMAGING AND SYSTEMATIC STEREOLOGY - RELATIONSHIP TO DEXAMETHASONE SUPPRESSION TEST-RESULTS IN PATIENTS [J].

AXELSON, DA ;

DORAISWAMY, PM ;

BOYKO, OB ;

ESCALONA, PR ;

MCDONALD, WM ;

RITCHIE, JC ;

PATTERSON, LJ ;

ELLINWOOD, EH ;

NEMEROFF, CB ;

KRISHNAN, KRR .

PSYCHIATRY RESEARCH, 1992, 44 (01) :63-70

[5]

Increase in concentration of waking salivary cortisol in recovered patients with depression [J].

Bhagwagar, Z ;

Hafizi, S ;

Cowen, PJ .

AMERICAN JOURNAL OF PSYCHIATRY, 2003, 160 (10) :1890-1891

[6]

BHAGWAGAR Z, 2005, PSYCHOPHARMACOLOGY B, P1

[7]

Effects of acute metabolic stress on the dopaminergic and pituitary-adrenal axis activity in patients with schizophrenia, their unaffected siblings and controls [J].

Brunelin, Jerome ;

d'Amato, Thierry ;

van Os, Jim ;

Cochet, Alain ;

Suaud-Chagny, Marie-Frangoise ;

Saoud, Mohamed .

SCHIZOPHRENIA RESEARCH, 2008, 100 (1-3) :206-211

[8]

Pituitary volume increase during emerging psychosis [J].

Bueschlen, Jeannine ;

Berger, Gregor E. ;

Borgwardt, Stefan J. ;

Aston, Jacqueline ;

Gschwandtner, Ute ;

Pflueger, Marlon O. ;

Kuster, Pascal ;

Radue, Ernst Wilhem ;

Stieglitz, Rolf-Dieter ;

Riecher-Roessler, Anita .

SCHIZOPHRENIA RESEARCH, 2011, 125 (01) :41-48

[9]

Psychosis and brain volume changes during the first five years of schizophrenia [J].

Cahn, W. ;

Rais, M. ;

Stigter, F. P. ;

van Haren, N. E. M. ;

Caspers, E. ;

Pol, H. E. Hulshoff ;

Xu, Z. ;

Schnack, H. G. ;

Kahn, R. S. .

EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2009, 19 (02) :147-151

[10]

Cesková E, 2006, NEUROENDOCRINOL LETT, V27, P433

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