Gene-Environment Interaction in Genome-Wide Association Studies

被引：217

作者：

Murcray, Cassandra E. ^{[1
]}

Lewinger, Juan Pablo ^{[1
]}

Gauderman, W. James ^{[1
]}

机构：

[1] Univ So Calif, Dept Prevent Med, Los Angeles, CA 90089 USA

来源：

AMERICAN JOURNAL OF EPIDEMIOLOGY | 2009年 / 169卷 / 02期

关键词：

BREAST-CANCER; AIR-POLLUTION; SUSCEPTIBILITY; RISK; ASTHMA; LOCI; REPLICATION; CHILDREN; SMOKING;

D O I：

10.1093/aje/kwn353

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

It is a commonly held belief that most complex diseases (e.g., diabetes, asthma, cancer) are affected in part by interactions between genes and environmental factors. However, investigators conducting genome-wide association studies typically test for only the marginal effects of each genetic marker on disease. In this paper, the authors propose an efficient and easily implemented 2-step analysis of genome-wide association study data aimed at identifying genes involved in a gene-environment interaction. The procedure complements screening for marginal genetic effects and thus has the potential to uncover new genetic signals that have not been identified previously.

引用

页码：219 / 226

页数：8

共 24 条

[1]

[Anonymous], 1998, ASYMPTOTIC STAT, DOI DOI 10.1017/CBO9780511802256

[2] CONTROLLING THE FALSE DISCOVERY RATE - A PRACTICAL AND POWERFUL APPROACH TO MULTIPLE TESTING [J].

BENJAMINI, Y ;

HOCHBERG, Y .

JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-STATISTICAL METHODOLOGY, 1995, 57 (01) :289-300

[3] Efficient multilocus association testing for whole genome association studies using localized haplotype clustering [J].

Browning, Brian L. ;

Browning, Sharon R. .

GENETIC EPIDEMIOLOGY, 2007, 31 (05) :365-375

[4] Epidemiological methods for studying genes and environmental factors in complex diseases [J].

Clayton, D ;

McKeigue, PM .

LANCET, 2001, 358 (9290) :1356-1360

[5] Genome-wide association study identifies novel breast cancer susceptibility loci [J].

Easton, Douglas F. ;

Pooley, Karen A. ;

Dunning, Alison M. ;

Pharoah, Paul D. P. ;

Thompson, Deborah ;

Ballinger, Dennis G. ;

Struewing, Jeffery P. ;

Morrison, Jonathan ;

Field, Helen ;

Luben, Robert ;

Wareham, Nicholas ;

Ahmed, Shahana ;

Healey, Catherine S. ;

Bowman, Richard ;

Meyer, Kerstin B. ;

Haiman, Christopher A. ;

Kolonel, Laurence K. ;

Henderson, Brian E. ;

Le Marchand, Loic ;

Brennan, Paul ;

Sangrajrang, Suleeporn ;

Gaborieau, Valerie ;

Odefrey, Fabrice ;

Shen, Chen-Yang ;

Wu, Pei-Ei ;

Wang, Hui-Chun ;

Eccles, Diana ;

Evans, D. Gareth ;

Peto, Julian ;

Fletcher, Olivia ;

Johnson, Nichola ;

Seal, Sheila ;

Stratton, Michael R. ;

Rahman, Nazneen ;

Chenevix-Trench, Georgia ;

Bojesen, Stig E. ;

Nordestgaard, Borge G. ;

Axelsson, Christen K. ;

Garcia-Closas, Montserrat ;

Brinton, Louise ;

Chanock, Stephen ;

Lissowska, Jolanta ;

Peplonska, Beata ;

Nevanlinna, Heli ;

Fagerholm, Rainer ;

Eerola, Hannaleena ;

Kang, Daehee ;

Yoo, Keun-Young ;

Noh, Dong-Young ;

Ahn, Sei-Hyun .

NATURE, 2007, 447 (7148) :1087-U7

[6] Effect of exposure to traffic on lung development from 10 to 18 years of age: a cohort study [J].

Gauderman, W. James ;

Vora, Hita ;

McConnell, Rob ;

Berhane, Kiros ;

Gilliland, Frank ;

Thomas, Duncan ;

Lurmann, Fred ;

Avol, Edward ;

Kunzli, Nino ;

Jerrett, Michael ;

Peters, John .

LANCET, 2007, 369 (9561) :571-577

[7] The effect of air pollution on lung development from 10 to 18 years of age [J].

Gauderman, WJ ;

Avol, E ;

Gilliland, F ;

Vora, H ;

Thomas, D ;

Berhane, K ;

McConnell, R ;

Kuenzli, N ;

Lurmann, F ;

Rappaport, E ;

Margolis, H ;

Bates, D ;

Peters, J .

NEW ENGLAND JOURNAL OF MEDICINE, 2004, 351 (11) :1057-1067

[8] Sample size requirements for association studies of gene-gene interaction [J].

Gauderman, WJ .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 2002, 155 (05) :478-484

[9] Childhood asthma and exposure to traffic and nitrogen dioxide [J].

Gauderman, WJ ;

Avol, E ;

Lurmann, F ;

Kuenzli, N ;

Gilliland, F ;

Peters, J ;

McConnell, R .

EPIDEMIOLOGY, 2005, 16 (06) :737-743

[10] A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer [J].

Hunter, David J. ;

Kraft, Peter ;

Jacobs, Kevin B. ;

Cox, David G. ;

Yeager, Meredith ;

Hankinson, Susan E. ;

Wacholder, Sholom ;

Wang, Zhaoming ;

Welch, Robert ;

Hutchinson, Amy ;

Wang, Junwen ;

Yu, Kai ;

Chatterjee, Nilanjan ;

Orr, Nick ;

Willett, Walter C. ;

Colditz, Graham A. ;

Ziegler, Regina G. ;

Berg, Christine D. ;

Buys, Saundra S. ;

McCarty, Catherine A. ;

Feigelson, Heather Spencer ;

Calle, Eugenia E. ;

Thun, Michael J. ;

Hayes, Richard B. ;

Tucker, Margaret ;

Gerhard, Daniela S. ;

Fraumeni, Joseph F., Jr. ;

Hoover, Robert N. ;

Thomas, Gilles ;

Chanock, Stephen J. .

NATURE GENETICS, 2007, 39 (07) :870-874

← 1 2 3 →