Minimal incidence of serum antibodies reactive with intact primary isolate virions in human immunodeficiency virus type 1-infected individuals

被引：18

作者：

Cavacini, LA

Peterson, JE

Nappi, E

Duval, M

Goldstein, R

Mayer, K

Posner, MR

机构：

[1] Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA 02215 USA

[2] Harvard Univ, Sch Med, Boston, MA USA

[3] Fenway Community Hlth Ctr, Boston, MA USA

[4] Brown Univ, Sch Med, Pawtucket Mem Hosp, Dept Med, Pawtucket, RI USA

[5] Brown Univ, Sch Med, Pawtucket Mem Hosp, Div Infect Dis, Pawtucket, RI USA

来源：

JOURNAL OF VIROLOGY | 1999年 / 73卷 / 11期

关键词：

D O I：

10.1128/JVI.73.11.9638-9641.1999

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Immunoglobulin G reactive with primary isolate virions aas detected in 36% of serum samples from individuals infected with human immunodeficiency virus type 1. Of these individuals, serum samples from only 7% captured significant quantities of virus. Virion-specific antibody correlated with CD4 counts and, of more significance, primary isolate neutralization. Further dissection of this response should lead to the identification of antibodies and antigenic epitopes for vaccine purposes.

引用

页码：9638 / 9641

页数：4

共 26 条

[1] CELLULAR PROTEINS BOUND TO IMMUNODEFICIENCY VIRUSES - IMPLICATIONS FOR PATHOGENESIS AND VACCINES
ARTHUR, LO
BESS, JW
SOWDER, RC
BENVENISTE, RE
MANN, DL
CHERMANN, JC
HENDERSON, LE
[J]. SCIENCE, 1992, 258 (5090) : 1935 - 1938
[2] Host cell-dependent alterations in envelope components of human immunodeficiency virus type 1 virions
Bastiani, L
Laal, S
Kim, M
ZollaPazner, S
[J]. JOURNAL OF VIROLOGY, 1997, 71 (05) : 3444 - 3450
[3] CAVACINI LA, 1993, J ACQ IMMUN DEF SYND, V6, P353
[4] CAVACINI LA, 1995, J IMMUNOL, V155, P3638
[5] Phase I study of a human monoclonal antibody directed against the CD4-binding site of HIV type 1 glycoprotein 120
Cavacini, LA
Samore, MH
Gambertoglio, J
Jackson, B
Duval, M
Wisnewski, A
Hammer, S
Koziel, C
Trapnell, C
Posner, MR
[J]. AIDS RESEARCH AND HUMAN RETROVIRUSES, 1998, 14 (07) : 545 - 550
[6] Functional and molecular characterization of human monoclonal antibody reactive with the immunodominant region of HIV type 1 glycoprotein 41
Cavacini, LA
Emes, CL
Wisnewski, AV
Power, J
Lewis, G
Montefiori, D
Posner, MR
[J]. AIDS RESEARCH AND HUMAN RETROVIRUSES, 1998, 14 (14) : 1271 - 1280
[7] CAVACINI LA, 1994, J IMMUNOL, V152, P2538
[8] Covalently crosslinked complexes of human immunodeficiency virus type 1 (HIV-1) gp120 and CD4 receptor elicit a neutralizing immune response that includes antibodies selective for primary virus isolates
Devico, A
Silver, A
Thornton, AM
Sarngadharan, MG
Pal, R
[J]. VIROLOGY, 1996, 218 (01) : 258 - 263
[9] Interactions of polyclonal and monoclonal anti-glycoprotein 120 antibodies with oligomeric glycoprotein 120 glycoprotein 41 complexes of a primary HIV type 1 isolate: Relationship to neutralization
Fouts, TR
Trkola, A
Fung, MS
Moore, JP
[J]. AIDS RESEARCH AND HUMAN RETROVIRUSES, 1998, 14 (07) : 591 - 597
[10] STANDARDIZATION OF SENSITIVE HUMAN-IMMUNODEFICIENCY-VIRUS COCULTURE PROCEDURES AND ESTABLISHMENT OF A MULTICENTER QUALITY ASSURANCE PROGRAM FOR THE AIDS CLINICAL-TRIALS GROUP
HOLLINGER, FB
BREMER, JW
MYERS, LE
GOLD, JWM
MCQUAY, L
[J]. JOURNAL OF CLINICAL MICROBIOLOGY, 1992, 30 (07) : 1787 - 1794

← 1 2 3 →