Isolation and characterization of trioxyethylene-encapsulated gold nanoclusters functionalized with a single DNA strand

被引：21

作者：

Jhaveri, SD

Foos, EE

Lowy, DA

Chang, EL

Snow, AW

Ancona, MG ^{[1
]}

机构：

[1] USN, Res Lab, Washington, DC 20375 USA

[2] Nova Res, Alexandria, VA USA

来源：

NANO LETTERS | 2004年 / 4卷 / 04期

关键词：

D O I：

10.1021/nl0499591

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A scalable means of isolating significant quantities of trioxyethylene-encapsulated gold nanoclusters (GNCs) labeled with a single DNA strand is demonstrated. Quantitative characterization of the product is obtained using UV-vis absorbance spectroscopy. These methods of isolation and characterization of singly functionalized GNC-ssDNA conjugates are expected to aid development of nanoscience applications that use DNA molecular recognition for guiding self-assembly.

引用

收藏

页码：737 / 740

页数：4

相关论文

共 29 条

[1] Organization of 'nanocrystal molecules' using DNA [J].

Alivisatos, AP ;

Johnsson, KP ;

Peng, XG ;

Wilson, TE ;

Loweth, CJ ;

Bruchez, MP ;

Schultz, PG .

NATURE, 1996, 382 (6592) :609-611

[2] Real-time multicolor DNA detection with chemoresponsive diffraction gratings and nanoparticle probes [J].

Bailey, RC ;

Nam, JM ;

Mirkin, CA ;

Hupp, JT .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (44) :13541-13547

[3]

Bohren C., 1983, ABSORPTION SCATTERIN

[4] A fluorescence-based method for determining the surface coverage and hybridization efficiency of thiol-capped oligonucleotides bound to gold thin films and nanoparticles [J].

Demers, LM ;

Mirkin, CA ;

Mucic, RC ;

Reynolds, RA ;

Letsinger, RL ;

Elghanian, R ;

Viswanadham, G .

ANALYTICAL CHEMISTRY, 2000, 72 (22) :5535-5541

[5] Synthesis and characterization of water soluble gold nanoclusters of varied core size [J].

Foos, EE ;

Snow, AW ;

Twigg, ME .

JOURNAL OF CLUSTER SCIENCE, 2002, 13 (04) :543-552

[6] Thiol-terminated Di-, Tri-, and tetraethylene oxide functionalized gold nanoparticles: A water-soluble, charge-neutral cluster [J].

Foos, EE ;

Snow, AW ;

Twigg, ME ;

Ancona, MG .

CHEMISTRY OF MATERIALS, 2002, 14 (05) :2401-2408

[7] Optical properties of dye molecules adsorbed on single gold and silver nanoparticles [J].

Franzen, S ;

Folmer, JCW ;

Glomm, WR ;

O'Neal, R .

JOURNAL OF PHYSICAL CHEMISTRY A, 2002, 106 (28) :6533-6540

[8] Alkanethiolate gold cluster molecules with core diameters from 1.5 to 5.2 nm: Core and monolayer properties as a function of core size [J].

Hostetler, MJ ;

Wingate, JE ;

Zhong, CJ ;

Harris, JE ;

Vachet, RW ;

Clark, MR ;

Londono, JD ;

Green, SJ ;

Stokes, JJ ;

Wignall, GD ;

Glish, GL ;

Porter, MD ;

Evans, ND ;

Murray, RW .

LANGMUIR, 1998, 14 (01) :17-30

[9]

Jhaveri S, 2003, MATER RES SOC SYMP P, V735, P159

[10] Ion-induced discrete charging of immobilized water-soluble gold nanoclusters [J].

Jhaveri, SD ;

Lowy, DA ;

Foos, EE ;

Snow, AW ;

Ancona, MG ;

Tender, LM .

CHEMICAL COMMUNICATIONS, 2002, (14) :1544-1545