Plasminogen activator inhibitor 1: Physiological and pathophysiological roles

被引：193

作者：

Binder, BR ^{[1
]}

Christ, G ^{[1
]}

Gruber, F ^{[1
]}

Grubic, N ^{[1
]}

Hufnagl, P ^{[1
]}

Krebs, M ^{[1
]}

Mihaly, J ^{[1
]}

Prager, GW ^{[1
]}

机构：

[1] Univ Vienna, Dept Vasc Biol & Thrombosis Res, A-1090 Vienna, Austria

来源：

NEWS IN PHYSIOLOGICAL SCIENCES | 2002年 / 17卷

关键词：

D O I：

10.1152/nips.01369.2001

中图分类号：

Q4 [生理学];

学科分类号：

071003 [生理学];

摘要：

Plasminogen activator inhibitor 1 (PAI-1) inhibits plasminogen activators (u-PA and t-PA) by forming stable complexes endocytosed via a low-density lipoprotein receptor superfamily member-dependent mechanism. PAI-1 circulates actively in plasma and latently in platelets but is also secreted and deposited into the matrix by several cells, where it participates in tissue repair processes.

引用

收藏

页码：56 / 61

页数：6

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