Holding T cells in check - a new role for complement regulators?

被引：92

作者：

Longhi, MP ^{[1
]}

Harris, CL ^{[1
]}

Morgan, BP ^{[1
]}

Gallimore, A ^{[1
]}

机构：

[1] Cardiff Univ, Cardiff CF14 4XN, Wales

来源：

TRENDS IN IMMUNOLOGY | 2006年 / 27卷 / 02期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/j.it.2005.12.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Complement is not only part of the innate immune system, but has also been implicated in adaptive immunity. The role of complement and its regulatory proteins in modulating T cell activity has been the focus of several recent studies. These, which have included work on the membrane co-factor protein (MCP or CD46), decay accelerating factor (DAF or CD55) and CD59, indicate that complement regulators can influence the proliferative capacity of T cells and their ability to produce cytokines, influencing the outcome of a T cell response to a given antigen. Here we review these studies, which reveal another important link between the innate and the adaptive immune system.

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页码：102 / 108

页数：7

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