[Bis(2-methoxyethyl)amino]sulfur trifluoride, the deoxo-fluor reagent: Application toward one-flask transformations of carboxylic acids to amides

被引：57

作者：

White, JM ^{[1
]}

Tunoori, AR ^{[1
]}

Turunen, BJ ^{[1
]}

Georg, GI ^{[1
]}

机构：

[1] Univ Kansas, Dept Med Chem, Lawrence, KS 66045 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2004年 / 69卷 / 07期

关键词：

D O I：

10.1021/jo035658k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The use of the Deoxo-Fluor reagent is a versatile method for acyl fluoride generation and subsequent one-flask amide coupling. It provides mild conditions and facile purification of the desired products in good to excellent yields. We have explored the utility of this reagent for the one-flask conversion of acids to amides and Weinreb amides and as a peptide-coupling reagent.

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页码：2573 / 2576

页数：4

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