Use of anti-neurofilament antibody to identify paired-helical filaments in inclusion-body myositis

被引：44

作者：

Askanas, V

Alvarez, RB

Mirabella, M

Engel, WK

机构：

[1] Department of Neurology, Univ. of S. California Sch. of Med., Good Samaritan Hospital, Los Angeles, CA 90017-1912

来源：

ANNALS OF NEUROLOGY | 1996年 / 39卷 / 03期

关键词：

D O I：

10.1002/ana.410390318

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Paired-helical filaments (PHFs) are an important diagnostic criterion of the inclusion-body myositis (IBM) muscle biopsy; but, until now, their presence could be identified only by electronmicroscopy. In this report, we describe an easy immunocytochemical procedure, utilizing commercially available antibody, that enables reliable identification of muscle PHFs by light microscopy. This procedure greatly facilitates diagnosis of IBM.

引用

页码：389 / 391

页数：3

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