Frank A. Beach Award: Programming of neuroendocrine function by early-life experience: A critical role for the immune system

被引：38

作者：

Bilbo, Staci D. ^{[1
]}

机构：

[1] Duke Univ, Duke Inst Brain Sci, Dept Psychol & Neurosci, Durham, NC 27708 USA

来源：

HORMONES AND BEHAVIOR | 2013年 / 63卷 / 05期

关键词：

Neonate; Infection; Microglia; Development; Learning; Memory; Interleukin (IL)-1 beta; Obesity; TLR4; TOLL-LIKE RECEPTOR; INFLAMMATORY RESPONSE; MEMORY IMPAIRMENT; BRAIN-DEVELOPMENT; MATERNAL OBESITY; MICROGLIAL CELLS; FATTY-ACIDS; DUAL ROLE; INFECTION; EXPRESSION;

D O I：

10.1016/j.yhbeh.2013.02.017

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Many neuropsychiatric disorders are associated with a strong dysregulation of the immune system, and several have a striking etiology in development as well. Our recent evidence using a rodent model of neonatal Escherichia coli infection has revealed novel insight into the mechanisms underlying cognitive deficits in adulthood, and suggests that the early-life immune history of an individual may be critical to understanding the relative risk of developing later-life mental health disorders in humans. A single neonatal infection programs the function of immune cells within the brain, called microglia, for the life of the rodent such that an adult immune challenge results in exaggerated cytoldne production within the brain and associated cognitive deficits. I describe the important role of the immune system, notably microglia, during brain development and discuss some of the many ways in which immune activation during early brain development can affect the later-life outcomes of neural function, immune function, and cognition. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：684 / 691

页数：8

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